• Cx3cr1-cre;Ercc1-/fl mice

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    Microglia may experience higher levels of DNA damage and potential senescence due to internal factors.

  • Dan Lab sleep datasets for MCI-Park mice 24-hour recordings

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    Sleep-wake dataset for MCI-Park mice and wildtype controls from Dan Lab.

  • pAAV-hsyn-DIO-Rpl22l1-3Flag-2A-eGFP-WPRE

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    Expression of a Flag-tagged Rpl22I1 protein in cells expressing Cre recombinase allowing for the harvesting of actively transcribed mRNAs in that cell type.

  • Drd1-T2A-Cre mouse line

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    Dopamine D1 receptor cre knock in mouse line generated by the Costa lab.

  • Anxa1-P2A-Cre Mouse line

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    Anxa1-Cre knock-in mice express cre recombinase from the mouse Anxa1 promoter in Anxa1-expressing cells and subtypes of dopaminergic neurons. This strain is useful in studies of motor neuron deficits in Parkinson's disease.

  • Slc6a3-T2A-FlpO (DAT-flpO) Mouse Line

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    DAT-FlpO knock-in mice express optimized Flp recombinase (FlpO) from the mouse Slc6a3 (DAT) promoter in Slc6a3-expressing cells, including dopaminergic neurons. This strain is useful in studies of motor neuron deficits in Parkinson's disease.

  • Adora2a-T2A-FlpO Mouse Line

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    Adora2a-Cre line generated by Cyagen for the Costa lab crossed with a FlpO line.

  • Drd1-T2A-FlpO Mouse Line

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    Dopamine D1 receptor FlpO mouse line generated by the Costa lab at Cyagen using CRISPR/Cas-mediated genome engineering.

  • Adora2a-T2A-Cre Mouse Line

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    Adora2a-Cre line generated by Cyagen using CRISPR/Cas-mediated genome engineering for the Costa lab.

  • Ef1a-DIO-PSAML-141F,Y115F-GlyR-2A-FusionRed plasmid

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    Pharmacologically Selective Actuator Module, chimeric ligand-gated ion channels that can be used to manipulate electrophysiological activity.

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Aligning Science Across Parkinson's
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