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Parkinson’s disease modeling in regenerative spiny mice (Acomys dimidiatus) captures key disease-relevant behavioral, histological, and molecular signatures
onThis paper models PD for the first time in a unique regenerative mammalian model, spiny mice, finding that 6-OHDA and αSyn PFFs induce robust pathology.
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Adenosine in the brain: recent progress on detection, function and translation
onRecent advancements have expanded our understanding of adenosine in the brain, revealing its role in regulating brain circuits for sleep, movement, cognition, and more.
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Generation of knock-in Cre and FlpO mouse lines for basal ganglia and dopamine neuron investigation (CODE)
onThe software contained in this repository was used to analyze the whole-cell electrophysiology recordings of striatal spiny projection neurons and midbrain dopamine neurons.
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ASAP CRN Cloud Release Notes – Version 2.0.0
onVersion: 2.0.0 Release Date: December 11, 2024 This release notes document provides a concise overview of the updates and enhancements introduced in Version 2.0.0 of the CRN Cloud platform.
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ASAP CRN Cloud Release Notes – Version 1.0.0
onVersion: 1.0.0 Release Date: June 25, 2024 This release notes document provides a concise overview of the updates and enhancements introduced in Version 1.0.0 of the CRN Cloud platform.
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ASAP CRN Cloud Release Notes – Version 1.0.0-beta
onVersion: 1.0.0-beta Release Date: March 6, 2024 This release notes document provides a concise overview of the updates and enhancements introduced in Version 1.0.0-beta of the CRN Cloud platform.
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ASAP CRN Cloud Release Notes – Version 0.0.1
onVersion: 0.0.1 Release Date: November 10, 2023 This release notes document provides a concise overview of Version 0.0.1 of the CRN Cloud platform.
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Dephosphorylation of phosphorylated Rab GTPases by PPM phosphatases
onProtocol measures phosphoRab GTPase dephosphorylation with PPM phosphatases using purified phosphoRab GTPases. Substrates generated by phosphorylating Rab GTPases with MST3 kinase are included.
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Flowcytometry analysis of lysosomal pulldown with anti-TMEM192 magnetic beads from PBMCs
onMethod described for staining intact lysosomes with lysotracker for flow cytometry. Analysis provides quantitative indication of organelle enrichment in immunoprecipitation, serving as quality control.
