Data and code for “The gut microbiome promotes mitochondrial respiration in the brain of a Parkinson’s disease mouse model””

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Output Details

Description
Processed data and code for analysis and plotting for the publication "The gut microbiome promotes mitochondrial respiration in the brain of a Parkinson’s disease mouse model"
Identifier (DOI)
10.5281/zenodo.14560061
Tags
  • Alpha-synuclein
  • Microbiome
  • Mitochondrial dysfunction
  • Mouse
  • Mouse model
  • Proteomics
  • Transcriptomics
Team
Team Gradinaru and Team Sulzer
Program
Collaborative Research Network
Theme
Circuitry and Brain-Body Interactions Neuro-Immune Interactions

Related Research

The gut microbiome promotes mitochondrial respiration in the brain of a Parkinson’s disease mouse model

In this paper, the authors find that the gut microbiome increases mitochondrial respiration and oxidative stress in the brain, which enhances motor symptoms in a mouse model of PD.

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Protocol for CRISPR-based manipulation and visualization of endogenous α-synuclein in cultured mouse hippocampal neurons

Protocol for depleting or tagging endogenous α-syn using virally-delivered CRISPR-Cas9 in hippocampal neurons

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Characterizing Parkinson’s Disease Clinical and Biomarker Interactions in REM Sleep Behavior Disorder

a-syn SAA positivity, DaT positivity, and hyposmia are highly associated with each other. MDS Prodromal PD Probability scores may be useful predictors of near-term progression, and thus as a stratification factor in clinical research study design

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Aligning Science Across Parkinson's
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