Characterizing Parkinson’s Disease Clinical and Biomarker Interactions in REM Sleep Behavior Disorder
Output Details
Description
Hyposmia was strongly associated with reductions in striatal dopaminergic activity and α-syn SAA positivity. MDS Prodromal PD Probability Scores, which incorporate DaT and olfactory function, predicted SAA positivity and phenoconversion. Among six phenoconverters (RBD-PC), DaT positivity was much more common (80%) than in non-phenoconverters (10%), but no significant motor or non-motor symptom differences were observed between the two groups at baseline, likely due to the small sample size.
Identifier (DOI)
10.1101/2025.05.16.25327469
