HEK293T FBXO7-/-

By Felix Kraus, PhD, Jiuchun Zhang and J. Wade Harper

Output Details

Description
HEK293T cells with FBXO7/PARK15 deletion made by CRISPR/Cas9.
Tags
  • Human
  • Mitophagy
Team
Team Harper
Program
Collaborative Research Network
Theme
PD Functional Genomics

Meet the Authors

Related Research

PARK15/FBXO7 is dispensable for PINK1/Parkin mitophagy in iNeurons and HeLa cell systems

PINK1 and Parkin promote damaged mitochondria removal through Ub phosphorylation, Parkin activation. FBXO7 mutation in PD may not affect mitophagy in HeLa and neuron cells, suggesting it may not play a significant role in Parkin-dependent mitophagy.

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Key Resource Table for Segregated basal ganglia output pathways correspond to genetically divergent neuronal subclasses

Comprehensive key resource table for the publication: "Segregated basal ganglia output pathways correspond to genetically divergent neuronal subclasses", Mendelsohn et al 2025.

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Immunohistochemistry (Brain organoids)

Protocol for preparing brain organoid slides and performing immunostainings to analyze protein expression and localization in the 3D model.

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