Protocol selection for Saurat et al. CSC 2024 V.2

By Nathalie Saurat, PhD, Lorenz Studer, MD, Johannes Jungverdorben, PhD and Maliha Rahman, BA
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Output Details

Description
This is a protocol collection for the publication "Genome-wide CRISPR screen identifies neddylation as a regulator of neuronal aging and AD neurodegeneration" Saurat N et al. Cell Stem Cell 2024 The collection consists of 20 different protocols. Full manuscript can be found here: DOI: [10.1016/j.stem.2024.06.001](https://doi.org/10.1016/j.stem.2024.06.001)
Identifier (DOI)
10.17504/protocols.io.81wgbrm2ylpk/v2
Tags
  • Aging
  • Cell biology
  • Human
  • In Vitro
  • iPSC
Team
Team Studer
Program
Collaborative Research Network
Theme
PD Functional Genomics

Meet the Authors

Related Research

Genome-wide CRISPR screen identifies neddylation as a regulator of neuronal aging and AD neurodegeneration.

We found that neddylation-inhibition triggers age-related features in PSC-derived neurons for modeling AD or PD. This strategy can induce late-onset phenotypes including degeneration when applied to DA neurons from PD- versus isogenic control PSCs.

View Article

Code for splicing-accuracy-manuscript

Code used for manuscript: Splicing accuracy varies across human introns, tissues and age

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Single-cell spatial transcriptomic and translatomic profiling of dopaminergic neurons in health, aging, and disease

This study used two complementary approaches in a Parkinson's disease mouse model and revealed insights into dopaminergic neuron characteristics, aging markers, and potential disease genes like CASR.

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Aligning Science Across Parkinson's
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