Human Postmortem-Derived Brain Sequencing Collection (Harmonized Collection)

By Andy Henrie, Hampton Leonard, Heather Ward, Sreeganga Chandra, PhD, Biqing Zhu, Anthony Russo, MSc, Jae Min Park, BA, Lee Marshall, PhD, Kimberly Paquette, BA, Kaitlyn Westra, Andrew Pyman, Ellison Lopes, Celia Kun-Rodrigues, MSc, Rita Guerreiro, Anita Adami, MSc, Cole Wunderlich, BSc, Talitha Forcier, PhD, Raquel Garza, PhD, Annelies Quaegebeur, MD, PhD, Yogita Sharma, PhD, Oliver Tam, PhD, Geidy Serrano, PhD, Thomas Beach, Madison Cline, MSc, Zhixiang Liao, Idil Tuncali, MSc, Monika Sharma, PhD, Jacob Parker, PhD, Zechuan Lin, PhD, Jie Yuan, PhD, Nathan Haywood, BSc, Sean Simmons, PhD, Maoxuan Lin, PhD, Kwanho Kim, Xufei Teng, PhD, Daniel El Kodsi, PhD, Roger Barker, PhD, Jose Bras, PhD, Xianjun Dong, PhD, Molly Gale Hammell, PhD, Agnete Kirkeby, PhD, Joshua Levin, PhD, Le Zhang, PhD, David Hafler, Johan Jakobsson, PhD, Michael Lee, PhD and Clemens Scherzer, MD

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Description

The Human Postmortem-derived Brain Sequencing Collection is a harmonized repository comprised of sequencing data (Single-Nucleus RNA-seq and PolyA RNA-seq) contributed by ASAP CRN teams. The samples have been harmonized across cell ranger data. The current collection will be expanded and improved as additional Human PMDBS data is uploaded into the ASAP CRN Cloud. When complete, the collection will provide sequencing data produced by the following techniques: single-nucleus RNAseq, single-cell RNAseq, bulk RNA-seq, ATAC-seq, long read WGS, and single-nucleus multiome sequencing (paired snRNAseq, snATACseq).

Identifier (DOI)

10.5281/zenodo.8384742

Tags

CRN Cloud Platform

Team

Team Hafler, Team Lee, Team Jakobsson and Team Scherzer

Program

Collaborative Research Network

Theme

Neuro-Immune Interactions PD Functional Genomics

Meet the Authors

Andy Henrie
Hampton Leonard
Heather Ward
Sreeganga Chandra, PhD

Co-PI (Core Leadership): Team Hafler,

Yale University
Biqing Zhu

Key Personnel: Team Hafler,

Yale University
Anthony Russo, MSc

Key Personnel: Team Hafler,

Yale University
Jae Min Park, BA

Key Personnel: Team Hafler,

Yale University
Lee Marshall, PhD

Key Personnel: Team Lee,

Van Andel Institute
Kimberly Paquette, BA

Key Personnel: Team Lee,

Van Andel Institute
Kaitlyn Westra

Key Personnel: Team Lee,

Van Andel Institute
Andrew Pyman
Ellison Lopes
Celia Kun-Rodrigues, MSc

Key Personnel: Team Lee,

Van Andel Institute
Rita Guerreiro
Anita Adami, MSc

Key Personnel: Team Jakobsson,

Lund University
Cole Wunderlich, BSc

Key Personnel: Team Jakobsson,

Cold Spring Harbor Laboratory
Talitha Forcier, PhD

Key Personnel: Team Jakobsson,

NYU Grossman
Raquel Garza, PhD

Key Personnel: Team Jakobsson,

Lund University
Annelies Quaegebeur, MD, PhD

Key Personnel: Team Jakobsson,

University of Cambridge
Yogita Sharma, PhD

Key Personnel: Team Jakobsson,

Lund University
Oliver Tam, PhD

Key Personnel: Team Jakobsson,

New York University Langone Medical Center
Geidy Serrano, PhD

Key Personnel: Team Biederer, Team Scherzer,

Banner Sun Health Research Institute
Thomas Beach

Key Personnel: Team Scherzer, Team Voet, Team Biederer,

Banner Sun Health Research Institute
Madison Cline, MSc

Key Personnel: Team Scherzer,

Banner Health
Zhixiang Liao
Idil Tuncali, MSc

Key Personnel: Team Scherzer,

Brigham and Women's Hospital
Monika Sharma, PhD

Key Personnel: Team Scherzer,

Yale University
Jacob Parker, PhD

Key Personnel: Team Scherzer,

Yale University
Zechuan Lin, PhD

Key Personnel: Team Scherzer,

Brigham and Women's Hospital
Jie Yuan, PhD

Key Personnel: Team Scherzer,

Brigham and Women's Hospital
Nathan Haywood, BSc

Key Personnel: Team Scherzer,

Broad Institute
Sean Simmons, PhD

Key Personnel: Team Scherzer,

Broad Institute
Maoxuan Lin, PhD

Key Personnel: Team Scherzer,

Brigham and Women's Hospital
Kwanho Kim

Key Personnel: Team Scherzer,

Broad Institute
Xufei Teng, PhD

Key Personnel: Team Scherzer,

Brigham and Women's Hospital
Daniel El Kodsi, PhD

Key Personnel: Team Studer,

Brigham and Women's Hospital
Roger Barker, PhD

Co-PI (Core Leadership): Team Jakobsson,

University of Cambridge
Jose Bras, PhD

Co-PI (Core Leadership): Team Lee,

Van Andel Institute
Xianjun Dong, PhD

Co-PI (Core Leadership): Team Scherzer,

Yale University
Molly Gale Hammell, PhD

Co-PI (Core Leadership): Team Jakobsson,

Cold Spring Harbor Laboratory
Agnete Kirkeby, PhD

Co-PI (Core Leadership): Team Jakobsson,

University of Copenhagen
Joshua Levin, PhD

Co-PI (Core Leadership): Team Scherzer,

Broad Institute
Le Zhang, PhD

Collaborating PI: Team Hafler, Team De Camilli,

Yale University
David Hafler

Lead PI (Core Leadership): Team Hafler,

Yale University
Johan Jakobsson, PhD

Lead PI (Core Leadership): Team Jakobsson,

Lund University
Michael Lee, PhD

Lead PI (Core Leadership): Team Lee,

University of Minnesota
Clemens Scherzer, MD

Lead PI (Core Leadership): Team Scherzer,

Brigham & Women's Hospital