Lab Resource Archive

iPSCs from a British Caucasian male, modified with NEUROG2 using CRISPR/Cas9 in AAVS1 locus. Contains mutations in ARID2 (p.Pro197Hisfs*12) and COL3A1 (p.Gly1176Ser). Derived from skin fibroblasts of a 55-59-year-old male.

Expression plasmid for human proteasome subunits.

Expression plasmid for human proteasome subunits.

Expression plasmid for human proteasome subunits.

Expression plasmid for human proteasome subunits.

This Excel file lists all ATG3 discontinued research outputs as they were deemed to be "not effective."

Expresses mTagBFP2 along with an shRNA against rat PGK1.

Expresses mTagBFP2 along with an shRNA against rat DJ-1.

The iPSC lines used for the generation of the DJ1 L166P point mutation were from KOLF 2.1 J background (Pantazis et al., 2021).

The iPSC lines used for the generation of the DJ1 L166P point mutation were from KOLF 2.1 J background (Pantazis et al., 2021).

Transfer plasmid for lentiviral vector production expressing Hs ATP13A2 WT with hygromycin selection marker.

Transfer plasmid for lentiviral vector production expressing Hs ATP13A2 P652_E653 del with puromycin selection marker.

(https://docs.google.com/spreadsheets/d/1Wdx_852CaqRRkGTbrZTKnYch2eiRN74A/edit?usp=sharing&ouid=109625585762898855018&rtpof=true&sd=true) lists all ATG3 discontinued research outputs generated for https://www.biorxiv.org/content/10.1101/2023.07.17.549391v2 but not published in https://www.science.org/doi/10.1126/sciadv.adj8027 as they were deemed to be "not effective." These cell lines were replaced by another set published on the Hub.

Mammalian expression of ATG13 (363-517) with MBP tag.

Mammalian expression of GST tagged ATG13 (363-460).

Transgenic mouse model with decreased calb1 expression in DAT-expressing cells.

Collection of human pluripotent stem cell lines from Team Studer consisting of isogenic GBA, LRRK2, SNCA series across three genetic backgrounds, KI-reporter lines for TOMM20 for mitochondria, b-actin for cytoskeleton, LAMB1 for cell membrane and LAMP1 for lysosomes, a-synuclein overexpression lines for Lewy body-like aggregation models, and other hPSC resources.

Cell Line from an African American population. Knockout cell: Method=CRISPR/Cas9; HGNC; 24002; AZI2.

Knockout cell: Method=CRISPR/Cas9; HGNC; 24002; AZI2. Knockout cell: Method=CRISPR/Cas9; HGNC; 29912; CALCOCO2. Knockout cell: Method=CRISPR/Cas9; HGNC; 6746; NBR1. Knockout cell: Method=TALEN; HGNC; 17142; OPTN. Knockout cell: Method=CRISPR/Cas9; HGNC; 11280; SQSTM1. Knockout cell: Method=CRISPR/Cas9; HGNC; 11575; TAX1BP1. Knockout cell: Method=CRISPR/Cas9; HGNC; 30140; TBKBP1. Knockout cell: Method=CRISPR/Cas9; HGNC; 12558; ULK1. Knockout cell: Method=CRISPR/Cas9; HGNC; 13480; ULK2.

Cell Line from an African American population. Knockout cell: Method=CRISPR/Cas9; HGNC; 30140; TBKBP1.