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Catalog
ASAP is committed to accelerating the pace of discovery and informing a path to a cure for Parkinson’s disease through collaboration, research-enabling resources, and data sharing. We’ve created this catalog to showcase the research outputs and tools developed by ASAP-funded programs.
Article
Population fraction of Parkinson’s disease attributable to preventable risk factors
Published: The team identified repeated blows to head in sports/combat as a potential new risk factor. 23% of PD cases in females were attributable to pesticides/herbicides exposure, and 30% of PD in males were attributable to pesticides/herbicides, military-related chemical exposures, and repeated blows to the head, and therefore could have potentially been prevented. View original preprint.
Teams
Article
Alpha-synuclein overexpression can drive microbiome dysbiosis in mice
Growing evidence indicates that persons living with Parkinson’s disease (PD) have a unique composition of indigenous gut microbes. Here, the authors used a transgenic mouse strain, which overexpress wild-type human α-syn to test how the gut microbiome composition responds in this model of PD pathology during aging.
Article
A leaky gut dysregulates gene networks in the brain associated with immune activation, oxidative stress, and myelination in a mouse model of colitis
Preprint: The team provides a comprehensive evaluation of multiple systems in a prevalent experimental model of intestinal permeability, which will inform future studies using this model and others, assist in the identification of druggable targets in the gut-brain axis, and contribute to our understanding of the concomitance of intestinal and neuropsychiatric dysfunction.
Teams
Protocol
Harvesting and culturing of peritoneal macrophages and ex vivo stimulation
Harvesting and culturing of peritoneal macrophages and ex vivo stimulation with IFNy.
Teams
Dataset
CryoEM structure of amplified alpha-synuclein fibril class A type I with compact core from DLB case III
Classification: PROTEIN FIBRIL
Organism(s): Homo sapiens
Expression System: Escherichia coli ‘BL21-Gold(DE3)pLysS AG
Mutation(s): No
Teams
Dataset
CryoEM structure of amplified alpha-synuclein fibril class B type I with extended core from DLB case X
Classification: PROTEIN FIBRIL
Organism(s): Homo sapiens
Expression System: Escherichia coli ‘BL21-Gold(DE3)pLysS AG
Mutation(s): No
Teams
Dataset
CryoEM structure of amplified alpha-synuclein fibril class B type II with extended core from DLB case VII
Classification: PROTEIN FIBRIL
Organism(s): Homo sapiens
Expression System: Escherichia coli ‘BL21-Gold(DE3)pLysS AG
Mutation(s): No
Teams
Dataset
CryoEM structure of amplified alpha-synuclein fibril class B type I with extended core from DLB case VII
Classification: PROTEIN FIBRIL
Organism(s): Homo sapiens
Expression System: Escherichia coli ‘BL21-Gold(DE3)pLysS AG
Mutation(s): No
Teams
Dataset
CryoEM structures of amplified alpha-synuclein fibril class B type I with compact core from DLB case III
Classification: PROTEIN FIBRIL
Organism(s): Homo sapiens
Expression System: Escherichia coli ‘BL21-Gold(DE3)pLysS AG
Mutation(s): No
Teams
Dataset
CryoEM structures of amplified alpha-synuclein fibril class B mixed type I/II with extended core from DLB case II
Classification: PROTEIN FIBRIL
Organism(s): Homo sapiens
Expression System: Escherichia coli ‘BL21-Gold(DE3)pLysS AG
Mutation(s): No
Teams
Dataset
CryoEM structures of amplified alpha-synuclein fibril class B type II with extended core from DLB case I
Classification: PROTEIN FIBRIL
Organism(s): Homo sapiens
Expression System: Escherichia coli BL21(DE3)
Mutation(s): No
Teams
Article
Structural and functional landscape of α-synuclein fibrilconformations amplified from cerebrospinal fluid
Preprint: Using cryo-electron microscopy to look at alpha-synuclein structurs in the cerebral spinal fluid from those diagnosed with lewy body dementia, the authors identify novel structures highlighting the different ways that alpha-synucelin can fold and assemble.
Teams
Article
Anionic nanoplastic contaminants promote Parkinson’s disease–associated α-synuclein aggregation
These results highlight a potential link for further exploration between nanoplastic pollution and α-synuclein aggregation associated with Parkinson’s disease and related dementias.
Teams
Dataset
CryoEM structures of amplified alpha-synuclein fibril class A type I with extended core from DLB case I
Classification: PROTEIN FIBRIL
Organism(s): Homo sapiens
Expression System: Escherichia coli BL21(DE3)
Mutation(s): No
Teams