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Catalog
ASAP is committed to accelerating the pace of discovery and informing a path to a cure for Parkinson’s disease through collaboration, research-enabling resources, and data sharing. We’ve created this catalog to showcase the research outputs and tools developed by ASAP-funded programs.
Article
Structural and functional landscape of α-synuclein fibrilconformations amplified from cerebrospinal fluid
Preprint: Using cryo-electron microscopy to look at alpha-synuclein structurs in the cerebral spinal fluid from those diagnosed with lewy body dementia, the authors identify novel structures highlighting the different ways that alpha-synucelin can fold and assemble.
Teams
Article
Metagenomics of Parkinson’s disease implicates the gut microbiome in multiple disease mechanisms
Published: This work looked at a recently generated gut metagenome dataset and characterized the altered PD microbiome at species, gene, and pathway levels. They found 30% of species and pathways either elevated or depleted in PD, depicting a far more complex and widespread dysbiosis than previously known. View original preprint.
Teams
Article
Calcium influx into astrocytes plays a pivotal role in inflammation-driven behaviors
Graphical abstract.
Teams
Article
The R1441C-LRRK2 mutation induces myeloid immune cell exhaustion in an age- and sex-dependent manner
Preprint: LRRK2 has become an appealing target in PD, but findings suggest that more research is required to understand the cell-type-specific consequences and optimal timing of LRRK2-targeting therapeutics.
Teams
Article
A leaky gut dysregulates gene networks in the brain associated with immune activation, oxidative stress, and myelination in a mouse model of colitis
Preprint: The team provides a comprehensive evaluation of multiple systems in a prevalent experimental model of intestinal permeability, which will inform future studies using this model and others, assist in the identification of druggable targets in the gut-brain axis, and contribute to our understanding of the concomitance of intestinal and neuropsychiatric dysfunction.
Teams
Article
Anionic nanoplastic contaminants promote Parkinson’s disease–associated α-synuclein aggregation
These results highlight a potential link for further exploration between nanoplastic pollution and α-synuclein aggregation associated with Parkinson’s disease and related dementias.
Teams
Article
Microbial amyloids in neurodegenerative amyloid diseases
Published: Inhibiting microbial amyloids or their interactions with the host, may therefore represent a tangible target to limit various amyloid pathologies.
Teams
Article
Gut mucosal cells transfer α-synuclein to the vagus nerve
Published: These findings highlight a potential non-neuronal source of fibrillar α-synuclein protein that might arise in gut mucosal cells. View original preprint.
Teams
Article
Alpha-synuclein overexpression can drive microbiome dysbiosis in mice
Growing evidence indicates that persons living with Parkinson’s disease (PD) have a unique composition of indigenous gut microbes. Here, the authors used a transgenic mouse strain, which overexpress wild-type human α-syn to test how the gut microbiome composition responds in this model of PD pathology during aging.
Article
Microbiome-based biomarkers to guide personalized microbiome-based therapies for Parkinson’s disease
Not all persons with PD have a dysbiotic microbiome, and not all dysbiotic PD microbiomes have the same features. The authors have developed an intuitive and easily modifiable method to identify the optimal candidates for microbiome-based clinical trials, and subsequently, for treatments that are personalized for each individual’s dysbiotic features.
Teams
Article
Central and peripheral innate and adaptive immunity in Parkinson’s disease
Parkinson’s disease (PD) is a multisystem disorder with characteristics of a chronic inflammatory disease. To develop effective immunomodulatory interventions to combat PD, researchers need to think innovatively about the implications of orchestrated central and peripheral innate and adaptive immune responses that occur as the disease begins and progresses.
Teams
Article
Population fraction of Parkinson’s disease attributable to preventable risk factors
Published: The team identified repeated blows to head in sports/combat as a potential new risk factor. 23% of PD cases in females were attributable to pesticides/herbicides exposure, and 30% of PD in males were attributable to pesticides/herbicides, military-related chemical exposures, and repeated blows to the head, and therefore could have potentially been prevented. View original preprint.
Teams