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Catalog
ASAP is committed to accelerating the pace of discovery and informing a path to a cure for Parkinson’s disease through collaboration, research-enabling resources, and data sharing. We’ve created this catalog to showcase the research outputs and tools developed by ASAP-funded programs.
Dataset
CryoEM structure of amplified alpha-synuclein fibril class A type I with extended core from DLB case X
Classification: PROTEIN FIBRIL
Organism(s): Homo sapiens
Expression System: Escherichia coli ‘BL21-Gold(DE3)pLysS AG
Mutation(s): No
Teams
Dataset
Examining the brain’s response to intestinal permeability and inflammation in the dextran sulfate sodium-induced colitis model
From the brain, cortex, hippocampus, ventral midbrain, and striatum were taken to examine both global and regionally-specific transcriptomic perturbances that emerge in response to gut leakiness. All tissues were assayed with high-throughput RNA sequencing.
Teams
Dataset
Alpha-synuclein fibril from spontaneous control
Classification: PROTEIN FIBRIL
Organism(s): Homo sapiens
Expression System: Escherichia coli ‘BL21-Gold(DE3)pLysS AG
Mutation(s): No
Teams
Dataset
CryoEM structure of amplified alpha-synuclein fibril class B type I with extended core from DLB case X
Classification: PROTEIN FIBRIL
Organism(s): Homo sapiens
Expression System: Escherichia coli ‘BL21-Gold(DE3)pLysS AG
Mutation(s): No
Teams
Dataset
CryoEM structure of amplified alpha-synuclein fibril class B type II with extended core from DLB case VII
Classification: PROTEIN FIBRIL
Organism(s): Homo sapiens
Expression System: Escherichia coli ‘BL21-Gold(DE3)pLysS AG
Mutation(s): No
Teams
Dataset
CryoEM structure of amplified alpha-synuclein fibril class B type I with extended core from DLB case VII
Classification: PROTEIN FIBRIL
Organism(s): Homo sapiens
Expression System: Escherichia coli ‘BL21-Gold(DE3)pLysS AG
Mutation(s): No
Teams
Dataset
CryoEM structures of amplified alpha-synuclein fibril class B type I with compact core from DLB case III
Classification: PROTEIN FIBRIL
Organism(s): Homo sapiens
Expression System: Escherichia coli ‘BL21-Gold(DE3)pLysS AG
Mutation(s): No
Teams
Dataset
CryoEM structures of amplified alpha-synuclein fibril class B mixed type I/II with extended core from DLB case II
Classification: PROTEIN FIBRIL
Organism(s): Homo sapiens
Expression System: Escherichia coli ‘BL21-Gold(DE3)pLysS AG
Mutation(s): No
Teams
Dataset
CryoEM structures of amplified alpha-synuclein fibril class B type II with extended core from DLB case I
Classification: PROTEIN FIBRIL
Organism(s): Homo sapiens
Expression System: Escherichia coli BL21(DE3)
Mutation(s): No
Teams
Dataset
CryoEM structure of amplified alpha-synuclein fibril class A type I with compact core from DLB case III
Classification: PROTEIN FIBRIL
Organism(s): Homo sapiens
Expression System: Escherichia coli ‘BL21-Gold(DE3)pLysS AG
Mutation(s): No
Teams
Dataset
CryoEM structures of amplified alpha-synuclein fibril class A type I with extended core from DLB case I
Classification: PROTEIN FIBRIL
Organism(s): Homo sapiens
Expression System: Escherichia coli BL21(DE3)
Mutation(s): No
Teams
Dataset
Characterizing dysbiosis of the Parkinson’s disease gut microbiome using shotgun metagenomics
To characterize the dysbiosis at species, gene family, and metabolic pathway resolution, the authors enrolled 490 PD and 234 age and geographically matched neurologically healthy individuals, collected stool and metadata, and conducted deep shotgun metagenomic sequencing of fecal DNA. Sequences and metadata are provided here.
Teams
Dataset
CryoEM structure of amplified alpha-synuclein fibril class A type I with extended core from DLB case VII
Classification: PROTEIN FIBRIL
Organism(s): Homo sapiens
Expression System: Escherichia coli ‘BL21-Gold(DE3)pLysS AG
Mutation(s): No
Teams