Vibrational Control of Complex Networks
By onComplex networks' stability is crucial, but real-time control can be challenging. This paper proposes using vibrational control on network edges instead of nodes to stabilize systems, providing graph-theoretic conditions and effective design methods.
Spatial transcriptomics reveals molecular dysfunction associated with cortical Lewy pathology Software: DaniellaDeWeerd/ObjectAndRegionSum: ObjectAndRegionSum
By onThis shiny app takes the output from the QUINT workflow and outputs to CSV files. One contains the object counts for certain relevant regions, and the other contains region sums for those same regions.
Parkinson’s Families Project: a UK-wide study of early onset and familial Parkinson’s disease
By onThe genetic variations in familial and early-onset Parkinson’s disease were studied. Most early-onset and familial PD cases do not have a known genetic cause, indicating that there are likely to be further monogenic causes for PD.
Cleaned datasets used to perform statistical analyses: “Parkinson’s Families Project: a UK-wide study of early onset and familial Parkinson’s disease”
By onStudy on early onset Parkinson's disease used a pseudo-anonymised dataset for statistical analyses. Clean data was used to analyze polygenic risk scores and principal components in two models.
SNP Array Genotyping and Phenotypic Data: “Parkinson’s Families Project: a UK-wide study of early onset and familial Parkinson’s disease”
By onStudy on Parkinson's disease families in the UK collected genotypic data from 698 samples using Illumina NeuroChip SNP Array and phenotypic data from 718 samples. The datasets are publicly accessible via EGA.
Cortical synaptic vulnerabilities revealed in an α-synuclein aggregation model of Parkinson’s disease
By onThis study reports that α-synuclein aggregation in the cortex is linked to progressively impaired synaptic connectivity as measured using imaging and functional approaches. These results provide insights into cortical synapse vulnerability in PD.
Transcriptomic analysis of colonic lamina propria cells in PINK1 KO mice compared to wild type following intestinal microbial infection
By onTranscriptomic analysis of colonic lamina propria cells in PINK1 KO mice compared to wild type following intestinal microbial infection
Prospects for Disease Slowing in Parkinson Disease
By onDespite advancements in understanding PD pathogenesis and developing targeted therapies, no treatment has proven effective in modifying the disease. This review discusses current pharmacological interventions in clinical trials for PD.
Presynapses are mitophagy pit stops that prevent axon degeneration
By onDefective neuronal mitophagy is linked to PD. Damaged axonal mitochondria accumulate at presynapses, sites of mitophagy initiation and autophagosome formation. of receptor mediated mitophagy with Roxadustat, reveals a potential therapeutic avenue.
README Guide for Code
By onThe purpose of this document is to provide guidance on how to write README files for code.
Segregated basal ganglia output pathways correspond to genetically divergent neuronal subclasses
By onOur findings in this paper provide a unifying logic for how the developmental specification of diverse SNr neurons relates to the anatomical organization of basal ganglia circuits controlling specialized downstream brain regions.
Brain infiltrating leukocytes (BILs) extraction
By onThis protocol details the extraction of brain infiltrating leukocytes (BILs).
Mitochondrial antigen presentation (MitAP) to primary 2C CD8 T (proliferation and suppression) assay
By onThis protocol details the mitochondrial antigen presentation (MitAP) to primary 2C CD8 T (proliferation and suppression) assay in vivo
Similarities and differences between nigral and enteric dopaminergic neurons unravel distinctive involvement in Parkinson’s disease
By onParkinson's disease affects both midbrain and enteric nervous system dopaminergic neurons. Shared factors and properties control their evolution, with potential for novel neurotrophic factors to be used as protection against PD symptoms in the ENS.
Interactions of dopamine, iron, and alpha-synuclein linked to dopaminergic neuron vulnerability in Parkinson’s disease and Neurodegeneration with Brain Iron Accumulation disorders
By onDopamine, alpha-syn, and iron dysregulation contribute to vulnerability of substantia nigra dopaminergic neurons in Parkinson's and related disorders. Understanding their interplay is crucial for developing treatments to prevent disease progression.
Gut microbiome-mediated regulation of neuroinflammation
By onGut microbiome influences neuroinflammatory disease through pathways, including metabolite production, immune cell trafficking, and vagus nerve. Research on gut-brain axis has promising implications for understanding and treating neuroinflammation.
Single nucleus transcriptomic dataset of AAV-infected mouse OE
By onSingle nucleus sequencing dataset from mouse murine olfactory epithelium exposed to 4 AAV serotypes via nasal lavage.The goal was to identify the best candidate for transduction of olfactory sensory neurons. Code is included with the dataset.
Computational analysis for “Comparative Analysis of AAV Serotypes for the Transduction of Olfactory Sensory Neurons” by Belfort and Jia et al. 2024
By onCode for snRNAseq dataset analysis of AAV-infected mouse olfactory epithelium. This code accompanies the manuscript: Comparative Analysis of AAV Serotypes for the Transduction of Olfactory Sensory Neurons by Belfort, Jia et al. 2024.
Comparative Analysis of AAV Serotypes for Transduction of Olfactory Sensory Neurons
By onThis study compared the efficacy and selectivity of 11 different AAV serotypes for the efficient and selective transduction of murine olfactory sensory neurons in vivo. The findings inform research approaches and gene therapy based initiatives.
Astrocyte generation
By onA protocol for generating astrocytes from cortical neural progenitor cells using a commercial astrocyte media (AM) is described.
