Evaluating the performance of polygenic risk profiling across diverse ancestry populations in Parkinson’s diseaseon
Objective: This study aims to address disparities in risk prediction by evaluating the performance of polygenic risk score (PRS) models using the 90 risk variants across 78 independent loci previously linked to Parkinson’s disease (PD) risk across seven diverse ancestry populations.
NeuroBooster Array: A genome-wide genotyping platform to study neurological disorders across diverse populationson
Preprint: People envisage this valuable tool will standardize genetic studies in neurological disorders across different ancestral groups, allowing researchers to perform genetic research inclusively and at a global scale.
Preprint: The authors studied 709 persons with PD, which show that the non-coding GBA1 rs3115534 risk variant is associated with increased RBD symptomatology in Nigerians with PD. Further research is required to assess association with polysomnography-defined RBD.
Genome-wide association identified novel etiological insights associated with Parkinson’s disease in African and African admixed populationson
The authors perform a comprehensive genome-wide assessment of PD in African and African admixed ancestry, characterizing population-specific risk, differential haplotype structure and admixture, coding, structural genetic variation, and polygenic risk profiling. The authors identified a novel common risk factor for PD and age at onset at the GBA1 locus, that was found to be rare in non-African/African admixed populations.
This release includes 7,462 additional new complex disease participants and 487 new monogenic disease participants, adding to the previous releases from the Complex and Monogenic Networks.
Published: The authors performed the first large-scale multi-ancestry meta-analysis of Parkinson’s disease with 49,049 cases, 18,785 proxy cases, and 2,458,063 controls, including individuals of European, East Asian, Latin American, and African ancestry. This work lays the groundwork for future efforts aimed at identifying PD loci in non-European populations. View original preprint.
Black and African American Connections to Parkinson’s Disease Study: Addressing Missing Diversity in Parkinson’s Disease Geneticson
Op-Ed: This article discusses the GP2 Black and African American Connections to Parkinson's Disease (BLAAC PD) study.
Underrepresented Populations in Parkinson’s Genetics Research: Current Landscape and Future Directionson
Review: This review provides an overview of research involving PD genetics in under-represented populations, setting a baseline to measure future impact. The authors found a significant lack of population diversity in PD research, highlighting the need for more representation. View original preprint.
The IPDGC/GP2 Hackathon – an open science event for training in data science, genomics, and collaboration using Parkinson’s disease dataon
Op-Ed: The authors outline the projects and results arising from the international ‘hackathon’, which was a 3-day collaborative event between the Global Parkinson’s Genetics Program (GP2) and the International Parkinson’s Disease Genomics Consortium (IPDGC).
This review provides an overview of research involving PD genetics in under-represented populations, setting a baseline to measure future impact. The authors found a significant lack of population diversity in PD research, highlighting the need for more representation. This is a preprint.
Published: The authors performed automated machine learning on multi-modal data from PPMI and validated in the PDBP dataset. Further, they built networks to identify gene communities specific to PD. The model they built can improve multi-omic predictions of PD and improves disease risk prediction. View original preprint.
A suite of tools used by GP2 to analyze data.
Review: This review discuss the need for, inclusion of, and barriers to understudied ancestral groups in PD genetics research. They also provide an overview of PD clinical genetics and describe the future of PD genetics through the lens of collaborative initiatives.
Op-Ed: This article summarizes The Global Parkinson’s Genetics Program (GP2) and outlines its mission, path, deliverables, and principles.
This blog written by Dr. Sara Bandres-Ciga highlights women in science within the GP2 network.
This blog written by Hampton Leonard, Dr. Mike Nalls, Yeajin Song, and Dan Vitale describes the first data release from GP2.
This blog written by Justin C. Solle, Claire Wegel, and Dr. Eline Appelmans outlines how to access GP2 on the AMP PD platform.
This blog written by Sumit Dey introduces the new PhD student trainees in the GP2 Underrepresented Populations PhD program in Asia and Latin America.
This blog written by Jonathan D. Jackson, Marissa Reynolds, and Angie V. Sanchez discusses how to overcome challenges of minority representation in PD research, specifically about in regards to the BLAAC PD study
Understanding Genetic Implications of the Black and African American Connections to Parkinson’s Disease Study (BLAAC PD)on
This blog written by Dr. Sara Bandres-Ciga, Justin C. Solle, Alyssa O’Grady, and Bernadette Siddiqi describes the BLAAC PD study funded by ASAP.