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Incentive valence differentially engages open- and closed-loop basal ganglia circuits during movement initiation
onThis study used neuroimaging to show a ventral putamen-centered open-loop circuit linking emotions and movement in humans. Contextual incentives influence which motor circuit is activated, shedding light on paradoxical kinesia in Parkinson's Disease.
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Extracellular space diffusion modelling identifies distinct functional advantages of archetypical glutamatergic and GABAergic synapse geometries
onWe modelled extracellular diffusion in super-resolved images of live brain tissue neuropil. We found that extracellular space geometry shapes local diffusion and this has functional implications for signaling arising from synaptic spill-over.
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Protocol for efficient CRISPRi-mediated silencing of retrotransposons in human pluripotent stem cells
onThis methods paper outlines silencing transposable elements in hiPSCs using CRISPRi. Describes gRNA design, validation via multiome approach. Enables functional studies on TE transcription in hiPSC models.
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Single cell eQTL mapping reveals convergent glial–neuronal risk architecture in Parkinson’s disease
onPopulation-scale, disease-context aware meta single-nucleus eQTLs mapping (N 1,197) in nine cell types from cortex and substantia nigra identifies 125 risk genes and cell types for PD GWAS signals.
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Striatal dopamine signals internal states related to behavioral performance over prolonged timescales in monkeys
onDopamine plays dual roles in behavior: fast reward prediction errors and slow motivational states. Dopamine release in monkeys' brain regions tracks performance changes, suggesting a single signal for both functions.
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FISH CODETECTION
onDIG and Fluorescein labeled riboprobes Fluorescent in situ hybridization Frozen brain sections
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An ImageJ/FIJI Preprocessing Workflow for Multi-Series Confocal Microscopy Datasets Prior To CellProfiler Analysis
onA workflow using ImageJ/FIJI aims to create three-slice MIPs from multi-series .czi files to capture weak signals. It involves extracting datasets, creating projections, and saving images for efficient analysis in CellProfiler.
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Health phenome of Parkinson’s patients reveals prominent mood-sleep cluster
onIn 933 PD cases vs 291 controls, mood/sleep disorders (depression, anxiety, apnea, RLS) were more common and clustered. Pesticides and head trauma raised odds; smoking lowered. 43% of PD had a mood/sleep disorder.
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Raw datasets for “Cholesterol Dysregulation in APOE4 Astrocytes Promotes α-Synuclein Pathology in miBrains, a Human Brain Tissue Model”
onThis dataset contains all primary data and quantifications
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Methods for “Cholesterol Dysregulation in APOE4 Astrocytes Promotes α-Synuclein Pathology in miBrains, a Human Brain Tissue Model”
onCollection of protocols used for the manuscript entitled "Cholesterol Dysregulation in APOE4 Astrocytes Promotes α-Synuclein Pathology in miBrains, a Human Brain Tissue Model".
