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PD-RISK Index: Piloting an unsupervised toolkit to identify adults with Parkinson disease
onWe have successfully validated a simplified tool to detect Parkinson's for screening and diagnostic purposes. The PD-RISK toolkit comprises a self-reported 11-item questionnaire, an 8-scent smell test and an integrated score termed the PD-RISK Index.
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Code used in article: PD-RISK Index: Piloting an unsupervised toolkit to identify adults with Parkinson disease
onWe have successfully validated a simplified tool to detect Parkinson's for screening and diagnostic purposes. The PD-RISK toolkit comprises a self-reported 11-item questionnaire, an 8-scent smell test and an integrated score termed the PD-RISK Index.
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An astrocytic AMPAR-dependent parity signal preserves synaptic strength
onUsing AstroHTP, we blocked astrocytic AMPARs and found that ongoing glutamate activity triggers strong postsynaptic LTD, suggesting astrocytes act as a parity signal that stabilizes active synapses.
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Human Wild-type alpha-synuclein protein expression and purification ASAP Modified
onThe protocol is designed for high-yield purification of human recombinant α-synuclein monomer.
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Mouse Striatal Astrocytes culture
onThis protocol describes how to obtain striatal astrocyte cultures from postnatal mice (P0-P3).
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Raw Data: Western Blot Images of PARK7 Protein Expression in Genetically Engineered Human iPSC Lines
onWestern blot images comparing PARK7 protein expression in KOLF2.1J versus gene-edited PARK7 knockout, Park7 C-Terminal HaloTag, and Park7 SNV lines.
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Incentive valence differentially engages open- and closed-loop basal ganglia circuits during movement initiation
onThis study used neuroimaging to show a ventral putamen-centered open-loop circuit linking emotions and movement in humans. Contextual incentives influence which motor circuit is activated, shedding light on paradoxical kinesia in Parkinson's Disease.
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FISH CODETECTION
onDIG and Fluorescein labeled riboprobes Fluorescent in situ hybridization Frozen brain sections
