-
Incentive valence differentially engages open- and closed-loop basal ganglia circuits during movement initiation
onThis study used neuroimaging to show a ventral putamen-centered open-loop circuit linking emotions and movement in humans. Contextual incentives influence which motor circuit is activated, shedding light on paradoxical kinesia in Parkinson's Disease.
-
-
FISH CODETECTION
onDIG and Fluorescein labeled riboprobes Fluorescent in situ hybridization Frozen brain sections
-
Structural remodeling of the mitochondrial protein biogenesis machinery under proteostatic stress
onCryo-ET showed protein aggregates, altered cristae, and reduced ribosome complexes in stressed mitochondria. Mitochondrial Hsp60 undergoes conformational changes to aid in protein folding, shedding light on mitochondrial proteostasis mechanisms.
-
Solutions used for FISH Codetection
onProtocol to make the solutions used in the protocol published by AWM lab for FISH Codetection
-
Selective loss of Primary Cilia and Neurotrophic Signaling in G51D α-Synuclein Mice Highlights a Common Pathway to Parkinson’s Disease
onG51D α-synuclein mice mimic disease symptoms, showing cilia loss in specific neurons and impaired neurotrophic signaling, contributing to disease progression. This highlights the role of ciliary dysfunction in Parkinson’s.
-
Elevated phosphorylated α-synuclein and phosphorylated tau in Lrrk2 p.G2019S-mutant mice following influenza A pneumonitis
onInfluenza virus infection does not alter acute sickness in mice with Lrrk2 mutations. Surviving Lrrk2 p.G2019S KI mice, however, had elevated oxidative stress and phosphorylated a-synuclein and tau proteins in their brains six weeks post-infection.
-
Activation of transposable elements is linked to a region- and cell-type-specific interferon response in Parkinson’s disease
onStudy explores transposable elements role in Parkinson's disease neuroinflammation. TE activation in specific brain regions correlates with innate immune responses, indicating potential involvement in chronic neuroinflammation and PD progression.
-
Robust analytical methods for bis(monoacylglycero)phosphate profiling in health and disease
onBMP is a crucial phospholipid in lysosomes, impacting metabolic balance and linked to neurodegenerative diseases. LC-MS methods are detailed for accurate BMP analysis, utilizing structural differences and a new CLN5 function for profiling.
-
Integrated Representations of Threat and Controllability in the Lateral Frontal Pole
onEmotions can strongly influence behavior, as seen in PD paradoxical kinesia. Here, we demonstrate that anticipating threats enhances motor accuracy through interactions between the amygdala and the anterior pole of the lateral prefrontal cortex.
