Dopamine transporter imaging predicts clinically‐defined α‐synucleinopathy in REM sleep behavior disorder

By Lana M. Chahine, Michael Brumm, Chelsea Caspell-Garcia, Wolfgang Oertel, Brit Mollenhauer, MD, Amy W. Amara, Ana Fernandez-Arcos, Eduardo Tolosa, Cristina Simonet, Birgit Hogl, Aleksandar Videnovic, Samantha Hutten, Caroline M. Tanner, Daniel Weintraub, Elliot Burghardt, Christopher S. Coffey, Hyunkeun Ryan Cho, Karl Kieburtz, Kathleen Poston, MD, Kalpana Merchant, PhD, Douglas Galasko, Tatiana Foroud, Andrew Siderowf, Ken Marek, MD, Tanya Simuni, MD, Alex Iranzo

Published December 15, 2020

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Description

Individuals with idiopathic rapid eye movement sleep behavior disorder (iRBD) are at high risk for a clinical diagnosis of an α‐synucleinopathy (aSN). They could serve as a key population for disease‐modifying trials. Abnormal dopamine transporter (DAT) imaging is a strong candidate biomarker for risk of aSN diagnosis in iRBD. Our primary objective was to identify a quantitative measure of DAT imaging that predicts diagnosis of clinically‐defined aSN in iRBD.

Identifier (DOI)

10.1002/acn3.51269

Tags

Alpha-synuclein
DAT imaging
Original Research

Resource Team

Team PPMI

Program

Parkinson’s Progression Markers Initiative

Meet the Authors

Lana M. Chahine

External Collaborator
Michael Brumm

External Collaborator
Chelsea Caspell-Garcia

External Collaborator
Wolfgang Oertel

External Collaborator
Brit Mollenhauer, MD

Co-PI (Core Leadership): Team Schlossmacher, Team Muqit,

University of Göttingen
Amy W. Amara

External Collaborator
Ana Fernandez-Arcos

External Collaborator
Eduardo Tolosa

External Collaborator
Cristina Simonet

External Collaborator
Birgit Hogl

External Collaborator
Aleksandar Videnovic

External Collaborator
Samantha Hutten

External Collaborator
Caroline M. Tanner

External Collaborator
Daniel Weintraub

External Collaborator
Elliot Burghardt

External Collaborator
Christopher S. Coffey

External Collaborator
Hyunkeun Ryan Cho

External Collaborator
Karl Kieburtz

External Collaborator
Kathleen Poston, MD

Stanford University
Kalpana Merchant, PhD

Northwestern University
Douglas Galasko

External Collaborator
Tatiana Foroud

External Collaborator
Andrew Siderowf

External Collaborator
Ken Marek, MD

University of California, San Diego
Tanya Simuni, MD

Northwestern University
Alex Iranzo

External Collaborator