Impact of the dopamine system on long-term cognitive impairment in Parkinson disease: an exploratory study

By Daniel Weintraub, Marina Picillo, Hyunkeun Ryan Cho, Chelsea Caspell-Garcia, Cornelis Blauwendraat, PhD, Ethan G Brown, Lana M. Chahine, Christopher S. Coffey, Roseanne D. Dobkin, Tatiana Foroud, Douglas Galasko, Karl Kieburtz, Ken Marek, MD, Kalpana Merchant, PhD, Brit Mollenhauer, MD, Kathleen Poston, MD, Tanya Simuni, MD, Andrew Siderowf, Andrew Singleton, PhD, John Seibyl and Caroline M. Tanner

Published April 10, 2023

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Description

Background Little is known about the impact of the dopamine system on development of cognitive impairment (CI) in Parkinson disease (PD). Using data from a multi-site, international, prospective cohort study, authors explored the impact of dopamine system-related biomarkers on CI in PD. The study provides preliminary evidence that alterations in the dopamine system predict the development of clinically-relevant, cognitive impairment in Parkinson's disease. If replicated and determined to be causative, they demonstrate that the dopamine system is instrumental to cognitive health status throughout the disease course.

Identifier (DOI)

10.1002/mdc3.13751

Tags

Cognitive decline
Cognitive dysfunction/dementia
Dopamine
Imaging
Original Research

Program

Parkinson's Progression Markers Initiative

Meet the Authors

Daniel Weintraub

External Collaborator
Marina Picillo

External Collaborator
Hyunkeun Ryan Cho

External Collaborator
Chelsea Caspell-Garcia

External Collaborator
Cornelis Blauwendraat, PhD

Coalition for Aligning Science
Ethan G Brown

External Collaborator
Lana M. Chahine

External Collaborator
Christopher S. Coffey

External Collaborator
Roseanne D. Dobkin

External Collaborator
Tatiana Foroud

External Collaborator
Douglas Galasko

External Collaborator
Karl Kieburtz

External Collaborator
Ken Marek, MD

University of California, San Diego
Kalpana Merchant, PhD

Northwestern University
Brit Mollenhauer, MD

Co-PI (Core Leadership): Team Schlossmacher,

University of Goettingen
Kathleen Poston, MD

Stanford University
Tanya Simuni, MD

Northwestern University
Andrew Siderowf

External Collaborator
Andrew Singleton, PhD

Global Parkinson's Genetics Program
John Seibyl

External Collaborator
Caroline M. Tanner

External Collaborator