Longitudinal Analysis of Multiple Neurotransmitter Metabolites in Cerebrospinal Fluid in Early Parkinson’s Disease

By Thomas Kremer, Kirsten I Taylor, Juliane Siebourg-Polster, Thomas Gerken, Andreas Staempfli, Christian Czech, Juergen Dukart, Douglas Galasko, Tatiana Foroud, Lana M. Chahine, Christopher S. Coffey, Tanya Simuni, MD, Daniel Weintraub, John Seibyl, Kathleen Poston, MD, Arthur Toga, Caroline M. Tanner, Ken Marek, MD, Samantha J. Hutten, Sebastian Dziadek, Caludia Trenkwalder, Gennaro Pagano and Brit Mollenhauer, MD

Published April 5, 2021

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Description

The aim of this study was quantification of multiple metabolites in CSF from PD versus healthy control subjects (HCs), including longitudinal analysis. Baseline levels of homovanillic acid (HVA) and 3,4-dihydroxyphenylacetic acid (DOPAC) were lower in individuals with PD compared with HCs. HVA levels correlated with Movement Disorder Society Unified Parkinson's Disease Rating Scale total scores (P < 0.01). Both HVA/dopamine and DOPAC/dopamine levels correlated with caudate nucleus and raw DOPAC with putamen dopamine transporter single-photon emission computed tomography uptake ratios (P < 0.01). No metabolite changed over 2 years in drug-naive individuals, but some changed on starting levodopa treatment.

Identifier (DOI)

10.1002/mds.28608

Tags

Brief Communication
CSF (Cerebral Spinal Fluid)
Dopamine
Fluid-based biomarkers

Program

Parkinson's Progression Markers Initiative

Meet the Authors

Thomas Kremer

External Collaborator
Kirsten I Taylor

External Collaborator
Juliane Siebourg-Polster

External Collaborator
Thomas Gerken

External Collaborator
Andreas Staempfli

External Collaborator
Christian Czech

External Collaborator
Juergen Dukart

External Collaborator
Douglas Galasko

External Collaborator
Tatiana Foroud

External Collaborator
Lana M. Chahine

External Collaborator
Christopher S. Coffey

External Collaborator
Tanya Simuni, MD

Northwestern University
Daniel Weintraub

External Collaborator
John Seibyl

External Collaborator
Kathleen Poston, MD

Stanford University
Arthur Toga

External Collaborator
Caroline M. Tanner

External Collaborator
Ken Marek, MD

University of California, San Diego
Samantha J. Hutten

External Collaborator
Sebastian Dziadek

External Collaborator
Caludia Trenkwalder

External Collaborator
Gennaro Pagano

External Collaborator
Brit Mollenhauer, MD

Co-PI (Core Leadership): Team Schlossmacher,

University of Goettingen