LRRK2 N2081D iPSC

Research Community
Research Community

ASAP supports three programs and serves as a member of multiple consortia to advance research for the benefit of the global Parkinson’s disease community.
Explore
Highlights
Highlights

ASAP shares the impact that our initiative, network, and supported programs have had on providing new insights into Parkinson’s disease. Discover news, interviews, awards, and annual impact.
Explore
Open Science
Open Science

ASAP is dedicated to facilitating a research environment where meaningful collaboration, research-enabling resources, and data sharing provides the answers we need to understand, diagnose, and treat Parkinson’s disease. Discover our open science philosophy.
Explore
Tools & Resources
Tools & Resources

ASAP is committed to developing and openly sharing research outputs, including data, code, protocols, and key lab materials, to help the scientific community build upon existing work.
Explore

Description

Available at Jax: SNV/WT, REV/WT, and SNV/SNV of the N2081D LRRK2 variant. Associated with Parkinson's Disease with dementia. Parental line is KOLF2.1J (JIPSC1000)

Tags

hiPSCs (Human induced pluripotent stem cells)
iPSCs (Induced pluripotent stem cells)

Program

iNDI-PD

LRRK2 N2081D iPSC

Output Details

Related Research

A framework for efficient CRISPRi-mediated silencing of retrotransposons in human pluripotent stem cells

Activation of transposable elements is linked to a region- and cell-type-specific interferon response in Parkinson’s disease

Expansion and maintenance of human induced pluripotent stem cells (iPSCs)