Available at Jax: SNV/WT, SNV/SNV, and REV/REV of the T240M PRKN variant. Associated with Parkinson's Disease with dementia. Parental line is KOLF2.1J (JIPSC1000)
This methods paper outlines silencing transposable elements in hiPSCs using CRISPRi. Describes gRNA design, validation via multiome approach. Enables functional studies on TE transcription in hiPSC models.
Study explores transposable elements role in Parkinson's disease neuroinflammation. TE activation in specific brain regions correlates with innate immune responses, indicating potential involvement in chronic neuroinflammation and PD progression.
