Sex-stratified analysis of the potential association between PGLYRP2 rs892145 variant and Parkinson’s disease across diverse ancestral populations

Variants in PGLYRP2, particularly rs892145-T, have been suggested as Parkinson’s disease (PD) risk factors. We analyzed data from 31,334 PD patients and 17,772 controls across diverse ancestries. A significant sex-dependent effect of rs892145-T was observed in African (AFR) ancestry males (OR=0.73, 95%CI: 0.57-0.94, p=0.014). Gene-based analyses identified another variant, rs7251871-A, as significantly associated with PD in AFR males (OR=1.34, 95%CI:1.13-1.59, p=6.65E-04, Bonferroni p=0.0432). No associations were observed in other ancestries. Further studies are needed to understand PGLYRP2’s role in PD.