Article Archive

The study suggests that early circuit modulation could be an effective approach to alleviate symptoms associated with α-Syn pathology, necessitating studies of functional consequences of α-Syn aggregation.

Gut microbiome influences neuroinflammatory disease through pathways, including metabolite production, immune cell trafficking, and vagus nerve. Research on the gut-brain axis has promising implications for understanding and treating neuroinflammation.

This study compared the efficacy and selectivity of 11 different AAV serotypes for the efficient and selective transduction of murine olfactory sensory neurons in vivo. The findings inform research approaches and gene therapy-based initiatives.

The endolysosomal system regulates plasma membrane protein degradation and recycling, crucial for cell surface protein abundance. A toolkit was developed to study endosomes and lysosomes in neurons, aiding in understanding neurodegenerative diseases.

L-DOPA-induced dyskinesia is a common issue in Parkinson's disease due to dopamine therapy. These findings show that ensembles of behavior-encoding D1- and D2-SPNs form new combinations of hyperactive neurons mediating specific dyskinetic movements.

Baseline α-syn seeding activity and seed concentration were not statistically significantly associated with PD progression in the PPMI cohort.

A new SPOTlight reporter allows visualization of the integrated stress response (ISR) activity in specific cell types in transgenic mice, aiding in studying health and disease implications.

Human stem cells are used to create in vitro cortico-striatal-thalamic-cortical circuits, mimicking neural networks involved in neuropsychiatric disorders. This system allows the study of normal development and diseases like autism and Tourette syndrome.

Parkinson's disease (PD) involves dysregulated neuroimmune crosstalk and gut-brain axis inflammation. Gastrointestinal dysfunction is a common early symptom. Iron dysregulation and immune cell dysfunction may play a role, with shared features in PD an IBD.

The authors created a new collection of 24 genetically well-controlled Drosophila models of familial forms of Parkinsonism. Using unbiased behavioral screening and machine learning, they identified three clusters of mutants that converge.

Using a reporter mouse line expressing tdTomato under control of DAT promoter in the gut and single cell sequencing, the authors uncovered a novel population of DA neurons unique to the ENS which was ChAT/DAT-tdTomato-immunoreactive and expressed Grp, Calcb.

This book chapter will be published (open-access) in October 2024. Book title: Translational Methods for Parkinson’s Disease and Atypical Parkinsonism Research. Editors: Sergiu Groppa, Susanne Schneider.

Synucleinopathies like Parkinson’s disease dementia are linked to cognitive impairments due to Lewy bodies. Various methods, like genetic manipulation and toxin exposure, can model these pathologies in research to understand human diseases better.

During selective autophagy transmembrane, cargo receptors can trigger autophagy by recruiting different complexes and utilizing multiple pathways. This flexibility in autophagy initiation has important therapeutic implications.

PD and DLB involve α-syn inclusions in the amygdala affecting cognition and emotions. Cortico-amygdala synapses with α-syn aggregates show increased volume of synapses, potentially contributing to behavioral impairments.

The intraputaminal delivery of AAV9-SynA53T resulted in a widespread synucleinopathy throughout the cerebral cortex and substantia nigra in the non-human primate brain.

GEARBOCS is a non-invasive method for precise gene editing in astrocytes using CRISPR/Cas9. It allows knockout, tagging, and reporter knock-in strategies, revealing the roles of Sparcl1 and Vamp2 in synapse maintenance in the mouse visual cortex.

This study of MPTP-induced Parkinsonism in macaques indicates that changes in the timing of task-related neural activity of the internal segment of the globus pallidus (GPi) correlate with the severity of motor impairments.

High-resolution connectomics in human participants provides evidence for a non-canonical circuit linking the limbic ventral putamen to the motor cortex. The data is in line with previous findings in nonhuman primates.

Safinamide (SAF) is used for PD by enhancing dopamine signal. SAF prolongs recovery from dopamine-mediated firing inhibition in SNpc DAergic neurons, mildly compared to tranylcypromine, suggesting multiple sites of action for SAF's therapeutics.