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Development and characterization of a non-human primate model of disseminated synucleinopathy

By Alberto J Rico, PhD, Almudena Corcho, Julia Chocarro Garcia, MSc, Goiaz Ariznabarreta, Elvira Roda, Adriana Honrubia, Patricia Arnaiz, José Luis Lanciego, MD, PhD
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Output Details

Description
In this study, the performance and biodistribution of the retrogradely-spreading AAV9-SynA53T vector was evaluated in the NHP brain. Conducted intraparenchymal deliveries of viral suspensions in the left putamen gave rise to a disseminated synucleinopathy in a circuit-specific basis.
Tags
  • In Vivo
  • Non-human primate
Team
Team Vila
Program
Collaborative Research Network
Theme
Circuitry and Brain-Body Interactions

Meet the Authors

  • User avatar fallback logo

    Alberto J Rico, PhD

    Key Personnel: Team Vila, 

    CIMA Research Foundation

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    Almudena Corcho

    External Collaborator

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    Julia Chocarro Garcia, MSc

    Key Personnel: Team Vila, 

    Open University of Catalonia

  • User avatar fallback logo

    Goiaz Ariznabarreta

    Key Personnel: Team Vila, 

    CIMA Research Foundation

  • User avatar fallback logo

    Elvira Roda

    Environmental Development Centre

  • User avatar fallback logo

    Adriana Honrubia

    Key Personnel: Team Vila, 

    Environmental Development Centre

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    Patricia Arnaiz

    Key Personnel: Team Vila, 

    CIMA Research Foundation

  • José Luis Lanciego, MD, PhD

    Collaborating PI: Team Vila, 

    Biomedical Research Networking Center on Neurodegenerative Diseases

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Aligning Science Across Parkinson's
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