Cells maintain optimal levels of lysosome degradative activity to protect against pathogens, clear waste, and generate nutrients. Here, we show that LRRK2, a protein that is tightly linked to Parkinson’s disease, negatively regulates lysosome…
LRRK2, linked to Parkinson's disease, responds to lysosomal stress through distinct mechanisms involving lipidation of GABARAP and/or accumulation of Rabs on lysosomes. Understanding these pathways can shed light on Parkinson's disease pathogenesis.
