Protocols for “MAPL regulates gasdermin-mediated release of mtDNA from lysosomes to drive pyroptotic cell death”
By onThis work establishes a mitochondrial–lysosomal signaling axis in which MAPL-driven mtDNA export and gasdermin-mediated lysosomal permeabilization convert organelle stress into pyroptotic cell death.
Transcriptomics of primary bone marrow-derived macrophages from MAPL KO and control mice.
By onThis work establishes a mitochondrial–lysosomal signaling axis in which MAPL-driven mtDNA export and gasdermin-mediated lysosomal permeabilization convert organelle stress into pyroptotic cell death.
Protocols for “LRRK2 G2019S mutation incites increased cell-intrinsic neutrophil effector functions and intestinal inflammation in a model of infectious colitis.”
By onProtocols for "LRRK2 G2019S mutation incites increased cell-intrinsic neutrophil effector functions and intestinal inflammation in a model of infectious colitis."
Citrobacter rodentium Model of Enteropathogenic and Enterohemorrhagic (EPEC, EHEC) Escherichia coli Infection
By onPurpose: To outline preparation of inoculum and per os Citrobacter rodentium infection in mice.
