Incentive valence differentially engages open- and closed-loop basal ganglia circuits during movement initiation
By onThis study used neuroimaging to show a ventral putamen-centered open-loop circuit linking emotions and movement in humans. Contextual incentives influence which motor circuit is activated, shedding light on paradoxical kinesia in Parkinson's Disease.
FISH CODETECTION
By onDIG and Fluorescein labeled riboprobes Fluorescent in situ hybridization Frozen brain sections
Solutions used for FISH Codetection
By onProtocol to make the solutions used in the protocol published by AWM lab for FISH Codetection
Selective loss of Primary Cilia and Neurotrophic Signaling in G51D α-Synuclein Mice Highlights a Common Pathway to Parkinson’s Disease
By onG51D α-synuclein mice mimic disease symptoms, showing cilia loss in specific neurons and impaired neurotrophic signaling, contributing to disease progression. This highlights the role of ciliary dysfunction in Parkinson’s.
Elevated phosphorylated α-synuclein and phosphorylated tau in Lrrk2 p.G2019S-mutant mice following influenza A pneumonitis
By onInfluenza virus infection does not alter acute sickness in mice with Lrrk2 mutations. Surviving Lrrk2 p.G2019S KI mice, however, had elevated oxidative stress and phosphorylated a-synuclein and tau proteins in their brains six weeks post-infection.
Integrated Representations of Threat and Controllability in the Lateral Frontal Pole
By onEmotions can strongly influence behavior, as seen in PD paradoxical kinesia. Here, we demonstrate that anticipating threats enhances motor accuracy through interactions between the amygdala and the anterior pole of the lateral prefrontal cortex.
ATP13A4 gates extracellular polyamine levels to control excitatory synaptogenesis
By onPolyamines are crucial for brain function. ATP13A4 is the main polyamine transporter in astrocytes, impacting astrocyte morphology, synapse formation, and neurodevelopment. Mutations in ATP13A4 are linked to neurodevelopmental disorders.
State-dependent modulation of spiny projection neurons controls levodopa-induced dyskinesia in a mouse model of Parkinson’s disease
By onLID is poorly understood, our research on dyskinetic mice show SPNs' properties oscillate during LID and are influenced by dopamine and acetylcholine signaling. Targeting M1 receptors in iSPNs reduced LID severity and improved levodopa effects.
Data and Images for Tonic dendritic GABA release by substantia nigra dopaminergic neurons
By onData and Images for Tonic dendritic GABA release by substantia nigra dopaminergic neurons
Astrocytes mediate the dopaminergic modulation of tonic GABAergic signaling in substantia nigra
By onTo characterize the actions of dopamine on substantia nigra pars reticulata (SNr) GABAergic neurons, optogenetic and electrophysiological tools were used in ex vivo mouse brain slices to monitor synaptic transmission arising from neurons.
Rise-and-fall dynamics reveal a molecular and cellular vulnerability axis in prion-like α-synuclein propagation
By onThis study uses a mathematical model to analyze α-synuclein pathology in a Parkinson’s mouse model. It identifies a low-dimensional vulnerability axis linking regional dynamics to neuronal composition and gene expression.
Key Resource Table: Molecular analysis of network vulnerability to α-synuclein pathology reveals PAKs as therapeutic targets for Parkinson’s disease
By onKey resource table for Molecular analysis of network vulnerability to α-synuclein pathology reveals PAKs as therapeutic targets for Parkinson’s disease
5-HT4 Receptor Ligand RS67333 Modulates Striatal Acetylcholine and Dopamine Release via the Inhibition of Acetylcholinesterase
By onThe 5-HT4R agonist RS67333 modulates striatal acetylcholine and dopamine release through acetylcholinesterase inhibition, not 5-HT4R activation, highlighting its potential as an AChE inhibitor for brain disorders.
Datasets and Key Resources Table used in Qiao, Q. et al. (2026) 5-HT4 Receptor Ligand RS67333 Modulates Striatal Acetylcholine and Dopamine Release via the Inhibition of Acetylcholinesterase
By onThis repository contains: 1) Key Resources Table containing details on key resources and the persistent identifiers for protocols and code used and generated in this study; 2) Source Data; and 3) README file.
Quantifying Acetylcholinesterase (AChE) activity in striatal mouse brain tissue
By onThis protocol describes the steps to measure acetylcholinesterase (AChE) activity in mouse striatal brain tissue.
Custom scripts related to Qiao, Q. et al. (2026) 5-HT4 Receptor Ligand RS67333 Modulates Striatal Acetylcholine and Dopamine Release via the Inhibition of Acetylcholinesterase
By onThis repository contains scripts to analyse and plot data obtained from Fast-scan Cyclic Voltammetry (FCV) experiments and GRAB sensor imaging in ex vivo mouse brain slices.
Chromium single-nucleus RNA Sequencing using the 10x Genomics Chromium Platform
By onThis protocol describes the isolation, fluorescence-activated sorting, and sequencing of nuclei from mouse striatal tissue for single-nucleus RNA sequencing (snRNA-seq) using the 10x Genomics Chromium Next GEM Single Cell 3′ Gene Expression platform.
GRAB sensor (GRAB ACh or GRABDA) imaging in ex vivo mouse striatal slices
By onThis protocol describes how to image GRAB Acetylcholine (GRABACh) and GRAB Dopamine (GRABDA) sensor expression in ex vivo mouse striatal slices.
Immunofluorescence for tyrosine hydroxylase (TH) in mouse brain sections
By onThis protocol describes the immunohistochemical staining procedure for detecting Tyrosine Hydroxylase (TH) in mouse brain sections using primary antibodies and fluorescent-conjugated secondary antibodies.
