Zhai et al. 2025 Raw data
By onData includes immunohistochemistry images, two-photon images of patched neurons, whole-cell recordings for somatic excitability and Sr2+-oEPSC, spine density imaging, ACh sensor imaging, and dendritic excitability linescan data.
suny-downstate-medical-center/pd_m1_6ohda: M1_Control_6OHDA
By onLiqiang Chu et al found decreased excitability in these neurons in a Parkinson's mouse model. A simulation using NetPyNE was created to study the impact of the changed PT5B neuron on motor cortex spiking dynamics.
Simulated mouse primary motor cortex activity during control and decreased pyramidal tract neuron excitability in the parkinsonian condition
By onSixteen files were collected from 4 sets of simulations, each with control and Parkinsonian conditions in rest and activated states. Parkinsonian M1 simulations showed reduced PT5B neuron excitability. Simulations lasted 4.3 seconds.
Protocol for CRISPR-based manipulation and visualization of endogenous α-synuclein in cultured mouse hippocampal neurons
By onProtocol for depleting or tagging endogenous α-syn using virally-delivered CRISPR-Cas9 in hippocampal neurons
Calcium imaging in SMA and M1 of macaques
By onCalcium imaging with miniature microscopes reveals neuron activity patterns in deep layers of SMA and M1, showing synchronous activity and sequential activation.
Jaccard (coactivation) analysis outputs
By onJaccard values for calcium transients in M1 and SMA of macaques during spontaneous or task reaching behavior.
General descriptors of calcium activity in M1 and SMA cells
By onCalcium event rates, IEI CV, and event amplitude were measured in SMA and M1 cells during spontaneous or reaching tasks to analyze neural activity.
Matlab code: Determination of precisely timed sequences of calcium events
By onThe file "Identify_sequences.m' used to identify sequences of calcium imaging events.
Matlab code: Event-based analysis of calcium transients
By onMatlab algorithms to align raw calcium traces to behavioral events during a behavioral task.
Source data for “Sub-second characterization of locomotor activities of mouse models of Parkinsonism”
By onSource data for "Sub-second analysis of locomotor activity in Parkinsonian mice"
MonkeyLogic files for behavioral task
By onFolder includes timing (*.m) and parameter (*.txt) files for MonkeyLogic, used in single-target and two-target touchscreen tasks as described in a publication.
Western Blot – Ford Lab
By onThis protocol describes the solutions and steps for performing western blots.
Immunohistochemistry Protocol – Ford Lab
By onThis protocol describes the steps for performing immunohistochemistry.
Dataset for Article “Reduced striatal M4-cholinergic signaling following dopamine loss contributes to parkinsonian and l-DOPA–induced dyskinetic behaviors”
By onPrimary Dataset for article by Nielsen et al "Reduced striatal M4-cholinergic signaling following dopamine loss contributes to parkinsonian and l-DOPA–induced dyskinetic behaviors"
TRAP In Vivo Analysis
By onGitHub Code and data from Ryan et al., 2024. Includes TRAP_InVivo_Analysis.m for Plexon MAP data analysis, TRAP_Remove_INs.m for removing putative interneurons, and Summary.mat containing behavior/electrophysiology data used for Figures 1 and S1.
TRAP-Rabies-Analysis
By onStudy by Ryan et al., 2024 used mice injected with viruses to label neurons in the brain. Resource is GitHub code with Rabies_Analysis.m to analyze data to map neurons and Rabies_Summary.mat contains normalized data for figures 2 and S2.
Primary Dataset for article “Systems-level analyses dissociate genetic regulators of reactive oxygen species and energy production”
By onPrimary Dataset for article "Systems-level analyses dissociate genetic regulators of reactive oxygen species and energy production"
