Catalog

ASAP is committed to accelerating the pace of discovery and informing a path to a cure for Parkinson’s disease through collaboration, research-enabling resources, and data sharing. We’ve created this catalog to showcase the research outputs and tools developed by ASAP-funded programs.

Lab Resource

2CT-PacerRH

Bacterial protein expression of Pacer RH domain.

Lab Resource

2CT-PacerRH K534N

Bacterial protein expression of Pacer RH domain mutant.

Lab Resource

2CT-PacerRH K534N, R623T

Bacterial protein expression of Pacer RH domain mutant.

Lab Resource

2CT-PacerRH K534N, R623T, R628K

Bacterial protein expression of Pacer RH domain mutant.

Lab Resource

2CT-PacerRH R623T

Bacterial protein expression of Pacer RH domain mutant.

Lab Resource

2CT-PacerRH R628K

Bacterial protein expression of Pacer RH domain mutant.

Lab Resource

2GT-RAB7A Q67L

Bacterial protein expression of RAB7A mutant.

Article

3D bioprinting of human neural tissues with functional connectivity

Probing how human neural networks operate is hindered by the lack of reliable human neural tissues amenable to the dynamic functional assessment of neural circuits. Team Scherzer developed a 3D bioprinting platform to assemble tissues with defined human neural cell types in a desired dimension using a commercial bioprinter.

Protocol

3D FIBSEM CLEM

This protocol details the procedure of Correlative Light Microscopy and Electron Microscopy (CLEM) with 3D Focus Ion Beam Scanning Electron Microscopy (FIBSEM) technique in Zeiss Crossbeam 550 FIBSEM system.

Article

3D imaging of neuronal inclusions and protein aggregates in human neurodegeneration by multiscale X-ray phase-contrast tomography

Preprint: This study leverages X-ray phase-contrast tomography for detailed analysis of neurodegenerative diseases focusing on the 3D visualization and quantification of neuropathological features within fixed human postmortem tissue.

Code

3D printed MR-compatible stereotaxic frame for NHPs

A compact MRI-compatible stereotaxis suitable for a variety of NHP species (Macaca mulatta, Macaca fascicularis, and Cebus apella) that allows multimodal alignment through technique-specific fiducial markers.