A data repository for the study of Alpha-synuclein aggregates trigger anti-viral immune pathways and RNA editing in human astrocytes
By onA data repository for the study of Alpha-synuclein aggregates trigger anti-viral immune pathways and RNA editing in human astrocytes
The mitochondrial unfolded protein response promotes senescence in human microglia by increasing S-adenosylmethionine availability for polyamine synthesis
By onMitochondria have a response to stress called UPRmt, aiding proteostasis. In humans, UPRmt affects microglia, causing metabolic changes and disrupting communication, leading to dysfunction and inflammation, impacting brain aging and disease.
Datasets and Key Resources Table used in Stedehouder & Roberts (2024) “Rapid modulation of striatal cholinergic interneurons and dopamine release by satellite astrocytes”
By onThis repository contains a Key Resources Table with details on lab materials and the persistent identifiers for protocols and code used and generated in this study; and tabular datasets shown in main and supplementary figures.
Additional data repository for the study of Alpha-synuclein aggregates trigger anti-viral immune pathways and RNA editing in human astrocytes
By onZip file 1: astrocytes calcium data measured using Fura 2 Zip file2: astrocytes ROS measured using DHE (Dihydroethidium) Zip file 3: astrocytes cell death measured using Sytox green
Raw files for Part1: Endogenous LRRK2 and PINK1 function in a convergent neuroprotective ciliogenesis pathway in the brain
By onAll data presented in Figure 1, 3, 4 and 5
The pyrethroid insecticide deltamethrin disrupts neuropeptide and monoamine signaling pathways in the gastrointestinal tract
By onEnteroendocrine cells in the intestine produce hormones affecting motility. Pyrethroids, common insecticides, impact these cells, leading to altered hormone release and intestinal motility, potentially contributing to various diseases.
Raw files for Part3: Endogenous LRRK2 and PINK1 function in a convergent neuroprotective ciliogenesis pathway in the brain
By onAll data presented in Figure 6
Raw files for Part2: Endogenous LRRK2 and PINK1 function in a convergent neuroprotective ciliogenesis pathway in the brain
By onAll data presented in Figure 2
A Vulnerable Subtype of Dopaminergic Neurons Drives Early Motor Deficits in Parkinson’s Disease
By onThis study uncovers the existence of a selectively vulnerable subtype of dopaminergic neurons (DANs) that is sufficient to drive early motor symptoms in Parkinson’s disease.
State-dependent modulation of spiny projection neurons controls levodopa-induced dyskinesia in a mouse model of Parkinson’s disease
By onLID is poorly understood, our research on dyskinetic mice show SPNs' properties oscillate during LID and are influenced by dopamine and acetylcholine signaling. Targeting M1 receptors in iSPNs reduced LID severity and improved levodopa effects.
pPB-EF1A-HALO-hLRRK2 (LIR2 mutant WTFI > ATFA)
By onpPB-EF1A-HALO-hLRRK2 (LIR2 mutant WTFI -> ATFA) plasmid
pPB-EF1A-HALO-hLRRK2 (LIR1 mutant WEVL > AEVA)
By onpPB-EF1A-HALO-hLRRK2 (LIR1 mutant WEVL -> AEVA) plasmid
Progressive noradrenergic degeneration and motor cortical dysfunction in Parkinson’s disease
By onThe article discusses clinical and preclinical studies that support the critical rolLC-NE neurodegeneration and motor cortical dysfunction in both motor and nonmotor deficits in Parkinsonian states.
pPB-EF1A-HALO-hLRRK2 (LIR1+2 mutant WEVL -> AEVA / WTFI > ATFA)
By onpPB-EF1A-HALO-hLRRK2 (LIR1+2 mutant WEVL -> AEVA / WTFI -> ATFA) plasmid
GRAB Acetylcholine (ACh) sensor imaging in ex vivo mouse striatal slices
By onProtocol for imaging GRAB Acetylcholine (ACh) sensor in mouse striatal slices and measuring changes in fluorescence signals due to ACh release is described.
Sub-second characterization of locomotor activities of mouse models of Parkinsonism
By onThis article documents robust changes in the velocity, usage, and temporal organization of behavioral modules and their responsiveness to dopaminergic treatment under the Parkinsonian state.
Dopamine and cortical iPSC-derived neurons with different Parkinsonian mutations show variation in lysosomal and mitochondrial dysfunction: implications for protein deposition versus selective cell loss
By onComparison of dopamine neurons identified lysosomal and mitochondrial dysfunction, as well as increased tau deposition, alpha-synuclein phosphorylation and decreased glucocerebrosidase activity.
Transgenic A53T mice have astrocytic a-synuclein aggregates in dopamine and striatal regions
By onUsing fluorescent immunohistochemistry, astrocyte subtypes were identified and aSyn burden quantified.
Unilateral 6-hydroxydopamine lesion mouse model of Parkinson’s disease
By onTo generate a mouse model of Parkinson's disease, unilateral injection of 6-OHDA(6-hydroxydopamine) into the medial forebrain bundle (MFB) was performed. Three to four weeks later, a drug-free cylinder test was used to assess the extent of lesion.
