Unilateral 6-hydroxydopamine lesion mouse model of Parkinson’s disease

By Cristina Alcacer, and Shenyu Zhai, PhD
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Output Details

Description
To generate a mouse model of Parkinson's disease, unilateral injection of 6-OHDA(6-hydroxydopamine) into the medial forebrain bundle (MFB) was performed. Three to four weeks later, a drug-free cylinder test was used to assess the extent of lesion.
Identifier (DOI)
10.17504/protocols.io.kqdg3q5w1v25/v1
Tags
  • 6-OHDA
  • Animal
  • Animal models
  • In Vivo
  • Mouse
  • Parkinson's disease
Team
Team Surmeier
Program
Collaborative Research Network
Theme
Circuitry and Brain-Body Interactions

Meet the Authors

  • User avatar fallback logo

    Cristina Alcacer,

  • User avatar fallback logo

    Shenyu Zhai, PhD

    Key Personnel: Team Surmeier, 

    Northwestern University

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