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Transgenic A53T mice have astrocytic a-synuclein aggregates in dopamine and striatal regions

By Cormac Peat, Glenda Halliday, PhD, Asheeta Prasad, PhD, Carolyn Sue, PhD, Jennifer Johnston, PhD, David Finkelstein, Clare Parish, PhD, Lachlan Thompson, PhD and Deniz Kirik, MD, PhD
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Output Details

Description
This study aimed to determine whether astrocytes accumulate a-synuclein before or after neurons, the present study histologically assessed astrocytes and a-synuclein accumulation in the M83 A53T transgenic mouse model of Parkinson’s disease prior to significant neuronal a-synuclein accumulation.
Identifier (DOI)
10.1101/2025.01.09.632283
Tags
  • Animal models
  • Astrocytes
  • Immunofluorescence
  • M83 A53T transgenic mouse model
  • Microscopy
  • Reactive astrocytes
Team
Team Kirik
Program
Collaborative Research Network
Theme
PD Functional Genomics

Meet the Authors

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Aligning Science Across Parkinson's
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