Structure and activation of the human autophagy-initiating ULK1C:PI3KC3-C1 supercomplex
By onOriginal gels with their repeats, associated with pre-print
Source data for Motor Cortical Neuronal Hyperexcitability Associated with α-Synuclein Aggregation
By onChen et al (2024) study links α-synuclein aggregation to hyperexcitability in motor cortical neurons.
Source data for the article “α-Synuclein aggregation decreases cortico-amygdala connectivity and impairs social behavior in mice”
By onα-Synuclein aggregation in mice reduces cortico-amygdala connectivity, leading to impaired social behavior.
DNA and Expression Following Nucleosome Depletion (DEFND) Sequencing on Cryopreserved Colon Tissue
By onThis protocol details DNA and Expression Following Nucleosome Depletion (DEFND) sequencing optimized for cryopreserved colon tissue.
Faecalibacterium prausnitzii, depleted in the Parkinson’s disease microbiome, improves motor deficits in α-synuclein overexpressing mice
By onTreatment with an 8-member consortium of bacteria depleted in PD patients, or the single member F. prausnitzii, improves motor and GI function and reduces αSyn aggregates in the brain of a mouse model of PD.
Motor behavior, GI behavior, protein, and volatile fatty acid assay data and analysis code associated with Moiseyenko et al. 2025
By onCode and data used for the statistical analysis of motor behavior and gut physiology tests, and downstream protein assays from Moiseyenko et al. (2025)
RNAseq data associated with Moiseyenko et al. 2025
By onBAM files for RNA sequencing of large intestine of wild-type, Thy1-ASO, and Faecalibacterium prausnitzii-treated Thy1-ASO mice from Moiseyenko et al. (2025)
Data and code for shotgun metagenomics associated with Moiseyenko et al. 2025
By onData and scripts to retrieve and analyze shotgun metagenomic data of wild-type, Thy1-ASO, and Faecalibacterium prausnitzii-treated Thy1-ASO mice from Moiseyenko et al. (2025)
Adult-specific Reelin expression alters striatal neuronal organization: implications for neuropsychiatric disorders
By onReelin levels might modulate the numbers of striatal interneurons and the density of the nigrostriatal dopaminergic projections, suggesting that these changes may be involved in the protection of Reelin against neuropsychiatric disorders.
A RAB7A Phosphoswitch Coordinates Rubicon Homology Protein Regulation of PINK1/Parkin-Dependent Mitophagy
By onPublished: Structural and functional data support a model in which the TBK1-dependent phosphorylation of RAB7A serves as a switch, promoting mitophagy by relieving Rubicon inhibition and favoring Pacer activation. View original preprint.
A data-driven single-cell and spatial transcriptomic map of the human prefrontal cortex
By onA data-driven molecular map of the DLPFC reveals distinct spatial domains and cell populations, offering insights into neuropsychiatric disorders. The study provides a roadmap for implementing spatial clustering approaches in the human brain.
EXPRESSION AND PURIFICATION OF HUMAN NEMO (GST-GFP-NEMO)
By onThis protocol describes how to express and purify human NEMO (IKK-γ) tagged N-terminally with GST and EGFP.
Integrated multi-cohort analysis of the Parkinson’s disease gut metagenome
By onThe authors perform metagenomic sequencing of multiple geographically-disparate cohorts and find that stereotypic changes in the functional metabolic potential of the gut microbiome are a consistent feature of PD.
A prebiotic diet modulates microglial states and motor deficits in α-synuclein overexpressing mice
By onWhat should Parkinson's Disease patients eat? This study shows that dietary fiber impacts gut microbes and immune cells in the brain of a mouse model of Parkinson's.
Evaluation Of The Rims2 Locus As A Risk Locus For Parkinson’s Disease Dementia
By onLiu et al. found RIMS2 locus linked to dementia in Parkinson's disease. Our study with 2536 individuals found no association with RIMS2 or other loci. More research is needed to uncover biological factors influencing Parkinson's dementia.
