Collaborative Research Network Archive

Emerging evidence suggests that non-coding RNAs (ncRNAs) contribute to molecular events underlying progressive neuronal degeneration. This review discusses recent literature focused on the role of RNA-based mechanisms involved in different aspects of neuronal pathology in Parkinson’s disease and synucleinopathy models.

This article describes the generation of the iPSC line FINi002-A from a male Parkinson's disease patient carrying compound heterozygous mutations in the PRKN gene.

Growing evidence indicates that persons living with Parkinson's disease (PD) have a unique composition of indigenous gut microbes. Here, the authors used a transgenic mouse strain, which overexpress wild-type human α-syn to test how the gut microbiome composition responds in this model of PD pathology during aging.

Fluorescence microscopy remains a widely applied experimental approaches in neuroscience and beyond and is continuously evolving to make it easier and more versatile. This review highlights the inherent limitations of fluorescence microscopy and conventional labeling and summarizes the pros and cons of recent shadow imaging approaches.

Central norepinephrine (NE) neurons, located mainly in the locus coeruleus (LC), are implicated in diverse psychiatric and neurodegenerative diseases and are an emerging target for drug discovery. To facilitate their study, the authors developed a method to generate 40–60% human LC-NE neurons from human pluripotent stem cells.