Transcriptomic profiling of human iPSC-derived midbrain astrocytes in ATP13A2 deficiency (c.1306) models
By onDataset compares gene expression in WT and ATP13A2 c.1306 mutants in midbrain astrocytes to understand transcriptional effects on neuroinflammation and lysosome dysfunction linked to early-onset Parkinson's Disease.
Code – bulkRNA-seq data from WT, ATP13A2 c.1306
By onCode - bulkRNA-seq data from WT, ATP13A2 c.1306 related to "ATP13A2 Loss of Function-Driven Polyamine Dysregulation Induces SAM Depletion and Epigenetic Astrocyte Toxicity"
DNA methylome profiling (Bisulfite Sequencing) of human iPSC-derived midbrain astrocytes in ATP13A2 c.1306deficiency models
By onDataset offers DNA methylation profiles of human midbrain astrocytes comparing ATP13A2 c.1306 mutants with Wild Type controls using WGBS.
quantification data related to “ATP13A2 Loss of Function-Driven Polyamine Dysregulation Induces SAM Depletion and Epigenetic Astrocyte Toxicity”
By onquantification data related to "ATP13A2 Loss of Function-Driven Polyamine Dysregulation Induces SAM Depletion and Epigenetic Astrocyte Toxicity"
bisulfite sequencing
By onbisulfite sequencing related to "ATP13A2 Loss of Function-Driven Polyamine Dysregulation Induces SAM Depletion and Epigenetic Astrocyte Toxicity"
bulkATAC-seq data from WT, ATP13A2 c.1306
By onbulkATAC-seq data from WT, ATP13A2 c.1306 related to "ATP13A2 Loss of Function-Driven Polyamine Dysregulation Induces SAM Depletion and Epigenetic Astrocyte Toxicity"
Modeling cis-regulatory variation in human brain enhancers across a large Parkinson’s Disease cohort
By onGWAS have linked more than hundred non-coding genomic loci to Parkinson’s disease (PD) risk. Here, we establish a unique resource and new sequence modeling strategies to interpret functional non-coding variation in the human brain.
Single nuclei RNA sequencing (ParseBio) of postmortem cingulate cortex,midbrain and motor cortex of healthy donors and Parkinson’s disease patients
By onThe dataset includes snRNA-seq data from postmortem brain samples of healthy donors, Parkinson's disease patients, and other neurological disorder patients.
Single nuclei RNA sequencing (10x) of postmortem cingulate cortex,midbrain and motor cortex of healthy donors and Parkinson’s disease patients – 10x snRNA-seq
By onDataset contains snRNA-seq data from postmortem brain samples of healthy donors, Parkinson's patients, and other neurological disorder patients.
Single nuclei RNA sequencing of postmortem cingulate cortex,midbrain and motor cortex of healthy donors and Parkinson’s disease patients – 10x multiome (snRNA-seq and snATAC-seq)
By onDataset includes snRNA-seq & snATAC-seq data from postmortem brain samples of healthy donors, Parkinson's patients, and other neurological disorders.
Single nuclei ATAC sequencing of postmortem cingulate cortex,midbrain and motor cortex of healthy donors and Parkinson’s disease patients – 10x snATAC-seq
By onThe dataset includes snATAC-seq data from postmortem brain samples of healthy donors, Parkinson's disease patients, and other neurological disorder patients.
Single nuclei ATAC sequencing of postmortem cingulate cortex,midbrain and motor cortex of healthy donors and Parkinson’s disease patients – Scale-ATAC + 10x Genomics
By onDataset contains ATAC-seq data from midbrain, cingulate cortex, and motor cortex of healthy donors, Parkinson's patients, and other neurological disorder patients.
Single nuclei ATAC sequencing of postmortem cingulate cortex,midbrain and motor cortex of healthy donors and Parkinson’s disease patients – HyDrop-ATAC v2
By onThe dataset contains snATAC-seq data from postmortem brain samples of healthy donors, Parkinson's disease patients, and other neurological disorder patients.
Single nuclei ATAC sequencing of postmortem cingulate cortex,midbrain and motor cortex of healthy donors and Parkinson’s disease patients – Scale-ATAC + HyDrop v2
By onThe dataset contains ATAC-seq data from midbrain, cingulate cortex, and motor cortex of healthy donors, Parkinson's patients, and others.
Nuclei isolation from brain tissue for single-cell ATAC
By onProtocol for isolating nuclei from brain tissue for single-cell ATAC assays like 10X Genomics Chromium Next GEM Single Cell ATAC Kit, HyDrop-ATAC, etc.
Nuclei isolation of fresh frozen human brain samples for for scRNA-seq
By onProtocol for isolating nuclei for single-cell RNA sequencing is detailed.
Long read whole genome sequencing data from brain postmortem tissue
By onDataset includes 172 whole genome sequencing runs from healthy controls and Parkinson's disease patients, sequenced on Oxford Nanopore platform. Data mapped to T2T-CHM13v2.0 reference genome, available in CRAM format.
HyDrop-v2-ATAC
By onProtocol covers nuclei preparation, ATAC tagmentation, microfluidics setup, HyDrop run, PCR1 cleanup, library purification, and quality control for efficient processing.
