LRRK2-mutant microglia and neuromelanin synergize to drive dopaminergic neurodegeneration in an iPSC-based Parkinson’s disease model
By onPD is a neurodegenerative disorder characterized by the loss of neuromelanin (NM)-containing dopamine neurons. This work highlights NM-activated microglia’s role in PD progression, and provides a model for testing therapeutic targets.
Version 1.0 Neuromelanin quantification R scripts
By onVersion 1.0 release of Neuromelanin quantification R scripts
Standardised TruAI automated quantification of intracellular neuromelanin granules in human brain tissue sections
By onNeuromelanin (NM) granules were analysed in human post-mortem formalin-fixed paraffin embedded (FFPE) midbrain sections.
Standardised TruAI Automated Quantification of Intracellular Neuromelanin Granules in Human Brain Tissue Sections
By onTo standardise and automate the quantitation of human-unique neuromelanin granules in catecholamine neurons in post-mortem tissue sections from healthy individuals at different ages to understand any changes in these granules with age.
MRI Datarat brain images used in “Longitudinal neuromelanin changes in prodromal and early Parkinson’s disease in humans and rat model”
By onThis Dataset contains rat brain images used in "Longitudinal neuromelanin changes in prodromal and early Parkinson’s disease in humans and rat ).
Collection of command-line Python-based scripts for voxel-wise computation
By onCollection of command-line Python-based scripts for voxel-wise computation
Script for rat brain images processing
By onScript for rat brain images processing used in https://doi.org/10.1101/2024.10.22.619619
Datsets of Article Navigation Journal Article Longitudinal neuromelanin changes in prodromal and early Parkinson’s disease in humans and rat model
By onDatsets of Article Longitudinal neuromelanin changes in prodromal and early Parkinson’s disease in humans and rat model
Longitudinal neuromelanin changes in prodromal and early Parkinson’s disease in humans and rat model
By onResults in animals and humans show that neuromelanin-sensitive-MRI is a marker of the intracellular neuromelanin accumulation and then of neuronal degeneration and originates mainly from T1 reduction effect of neuromelanin.
Sex-dimorphic effects of neuromelanin buildup in rodent nigral dopamine neurons: implications for sex-biased vulnerability in Parkinson’s disease
By onNeuromelanin (NM) is pigment accumulating with age in human SNpc dopamine (DA) neurons. This study discloses unrealized NM effects within nigral DA neurons, advancing our comprehension of sex-specific features shaping sex-biased vulnerability to PD.
Sex-dimorphic effects of neuromelanin buildup in rodent nigral dopamine neurons: implications for sex-biased vulnerability in Parkinson’s disease
By onNeuromelanin (NM) is pigment accumulating with age in human SNpc dopamine (DA) neurons. This study discloses unrealized NM effects within nigral DA neurons, advancing our comprehension of sex-specific features shaping sex-biased vulnerability to PD.
Introducing PIGMO, a novel PIGmented MOuse model of Parkinson’s disease
By onThere is a pressing need for the development of animal models of PD that properly mimic the its cardinal features. Here an AAV engineered to bypass the blood-brain barrier and coding for the human tyrosinase gene is used to generate the PIGMO model.
Datasets of Introducing PIGMO, a novel PIGmented MOuse model of Parkinson’s disease
By onThere is a pressing need for the development of animal models of PD that properly mimic the its cardinal features. Here an AAV engineered to bypass the blood-brain barrier and coding for the human tyrosinase gene is used to generate the PIGMO model.
Dan Lab sleep datasets for MCI-Park mice 24-hour recordings
By onSleep-wake dataset for MCI-Park mice and wildtype controls from Dan Lab.
pAAV-hsyn-DIO-Rpl22l1-3Flag-2A-eGFP-WPRE
By onExpression of a Flag-tagged Rpl22I1 protein in cells expressing Cre recombinase allowing for the harvesting of actively transcribed mRNAs in that cell type.
Drd1-T2A-Cre mouse line
By onDopamine D1 receptor cre knock in mouse line generated by the Costa lab.
Anxa1-P2A-Cre Mouse line
By onAnxa1-Cre knock-in mice express cre recombinase from the mouse Anxa1 promoter in Anxa1-expressing cells and subtypes of dopaminergic neurons. This strain is useful in studies of motor neuron deficits in Parkinson's disease.
Slc6a3-T2A-FlpO (DAT-flpO) Mouse Line
By onDAT-FlpO knock-in mice express optimized Flp recombinase (FlpO) from the mouse Slc6a3 (DAT) promoter in Slc6a3-expressing cells, including dopaminergic neurons. This strain is useful in studies of motor neuron deficits in Parkinson's disease.
