Immunostaining and Western blot images
By onRaw immunostaining and western blot images included in Adami et al, 2025.
CREsted: modeling genomic and synthetic cell type-specific enhancers across tissues and species
By onDeep learning models decode genomic regulatory codes well, especially enhancers. CREsted enables end-to-end enhancer modeling, design, and analysis, proving effective across datasets and species through comprehensive training and evaluation.
Tissue Isolation of the Region Around Locus Coeruleus for Single Nucleus RNA Profiling
By onIsolating tissue from the peri-locus coeruleus region in mice for single nucleus RNA
HyDrop v2: Scalable atlas construction for training sequence-to-function models
By onSingle-cell chromatin accessibility data helps train deep learning models to decode enhancer logic. HyDrop v2 improves data generation across species, organs, and diseases, delivering results comparable to commercial platforms like 10x Genomics.
Stereotaxic virus injection in the SNpc of rats
By onProtocol for stereotaxic virus injection in the substantia nigra pars compacta of rats
Optimized Stereotactic Injection Protocol for Targeting the Locus Coeruleus with Minimal Neurotoxicity
By onRefined stereotactic injection protocol targeting the Locus Coeruleus minimizes neurotoxicity.
Preparation of tissue punches of SNpc for the analyses of mitochondrial function
By onProtocol for the preparation of tissue punches of SNpc for the analyses of mitochondrial function
Preparation of midbrain slices for electrophysiology
By onProtocol for the preparation of midbrain slices for electrophysiology
Analyses of mitochondrial function in SNpc with the Seahorse XFe96
By onProtocol for analyses of mitochondrial function in SNpc with the Seahorse XFe96
Patch-clamp recordings of SNpc dopamine neurons from midbrain slices
By onProtocol for patch-clamp recordings of SNpc dopamine neurons from midbrain slices
WGS data related to “Is Gauchian genotyping of GBA1 variants reliable’
By onGauchian software helps identify GBA1 variants but struggles with rare ones due to database limitations, impacting diagnostic accuracy. Data from this study will aid future research on GBA1 variants.
AI-directed voxel extraction and volume EM identify intrusions as sites of mitochondrial contact
By onThe AI-directed Voxel Extraction (AIVE) segmentation strategy combines AI predictions with image electron signals to confidently segment membrane boundaries. Authors identify a new category of Membrane contact Sites named Mitochondrial Intrusions.
Mitophagy in Neurons: Mechanisms Regulating Mitochondrial Turnover and Neuronal Homeostasis
By onAuthors discuss the current understanding of mitophagy mechanisms operating in neurons to govern mitochondrial homeostasis and summarize progress on our understanding of the links between mitophagic dysfunction and neurodegeneration.
Development of a simplified smell test to identify Parkinson’s disease using multiple cohorts, machine learning and item response theory
By onReduced olfaction is a common feature of typical Parkinson disease (PD) and dementia with Lewy bodies (DLB). We have created a simplified smell test based on seven specific odorants that can distinguish PD/DLB patients from healthy controls.
Leveraging animal models to understand non-motor symptoms of Parkinson’s disease
By onParkinson's disease diagnosis focuses on motor symptoms, but non-motor symptoms like cognitive issues and sleep disorders significantly affect patients. Research on non-motor signs in animals aims to improve understanding of the disease.
Astrocytic polyamine transport by ATP13A4 tunes excitatory synaptic transmission
By onPolyamines are crucial for brain function. ATP13A4 is the main polyamine transporter in astrocytes, impacting astrocyte morphology, synapse formation, and neurodevelopment. Mutations in ATP13A4 are linked to neurodevelopmental disorders.
Original gels associated with PI3KC3-C1 activation paper
By onAll gels associated with protein purifications from VPS34/VPS15 publication
