Datsets of Article Navigation Journal Article Longitudinal neuromelanin changes in prodromal and early Parkinson’s disease in humans and rat model
By onDatsets of Article Longitudinal neuromelanin changes in prodromal and early Parkinson’s disease in humans and rat model
Longitudinal neuromelanin changes in prodromal and early Parkinson’s disease in humans and rat model
By onResults in animals and humans show that neuromelanin-sensitive-MRI is a marker of the intracellular neuromelanin accumulation and then of neuronal degeneration and originates mainly from T1 reduction effect of neuromelanin.
Sex-dimorphic effects of neuromelanin buildup in rodent nigral dopamine neurons: implications for sex-biased vulnerability in Parkinson’s disease
By onNeuromelanin (NM) is pigment accumulating with age in human SNpc dopamine (DA) neurons. This study discloses unrealized NM effects within nigral DA neurons, advancing our comprehension of sex-specific features shaping sex-biased vulnerability to PD.
Sex-dimorphic effects of neuromelanin buildup in rodent nigral dopamine neurons: implications for sex-biased vulnerability in Parkinson’s disease
By onNeuromelanin (NM) is pigment accumulating with age in human SNpc dopamine (DA) neurons. This study discloses unrealized NM effects within nigral DA neurons, advancing our comprehension of sex-specific features shaping sex-biased vulnerability to PD.
Introducing PIGMO, a novel PIGmented MOuse model of Parkinson’s disease
By onThere is a pressing need for the development of animal models of PD that properly mimic the its cardinal features. Here an AAV engineered to bypass the blood-brain barrier and coding for the human tyrosinase gene is used to generate the PIGMO model.
Datasets of Introducing PIGMO, a novel PIGmented MOuse model of Parkinson’s disease
By onThere is a pressing need for the development of animal models of PD that properly mimic the its cardinal features. Here an AAV engineered to bypass the blood-brain barrier and coding for the human tyrosinase gene is used to generate the PIGMO model.
Dan Lab sleep datasets for MCI-Park mice 24-hour recordings
By onSleep-wake dataset for MCI-Park mice and wildtype controls from Dan Lab.
pAAV-hsyn-DIO-Rpl22l1-3Flag-2A-eGFP-WPRE
By onExpression of a Flag-tagged Rpl22I1 protein in cells expressing Cre recombinase allowing for the harvesting of actively transcribed mRNAs in that cell type.
Drd1-T2A-Cre mouse line
By onDopamine D1 receptor cre knock in mouse line generated by the Costa lab.
Anxa1-P2A-Cre Mouse line
By onAnxa1-Cre knock-in mice express cre recombinase from the mouse Anxa1 promoter in Anxa1-expressing cells and subtypes of dopaminergic neurons. This strain is useful in studies of motor neuron deficits in Parkinson's disease.
Slc6a3-T2A-FlpO (DAT-flpO) Mouse Line
By onDAT-FlpO knock-in mice express optimized Flp recombinase (FlpO) from the mouse Slc6a3 (DAT) promoter in Slc6a3-expressing cells, including dopaminergic neurons. This strain is useful in studies of motor neuron deficits in Parkinson's disease.
Adora2a-T2A-FlpO Mouse Line
By onAdora2a-Cre line generated by Cyagen for the Costa lab crossed with a FlpO line.
Drd1-T2A-FlpO Mouse Line
By onDopamine D1 receptor FlpO mouse line generated by the Costa lab at Cyagen using CRISPR/Cas-mediated genome engineering.
Adora2a-T2A-Cre Mouse Line
By onAdora2a-Cre line generated by Cyagen using CRISPR/Cas-mediated genome engineering for the Costa lab.
Ef1a-DIO-PSAML-141F,Y115F-GlyR-2A-FusionRed plasmid
By onPharmacologically Selective Actuator Module, chimeric ligand-gated ion channels that can be used to manipulate electrophysiological activity.
RNA Seq dataset for: α-Synuclein pathology disrupts mitochondrial function in dopaminergic and cholinergic neurons at-risk in Parkinson’s disease
By onActively transcribed messenger ribonucleic acids (mRNAs) were harvested from SNc dopaminergic neurons in aSYN monomer or PFF-injected mice 12 weeks post injection and then subjected to RNASeq analysis.
pAAV-Con/Fon-N2cG
By onThis plasmid was generated by Columbia University Zuckerman Institute Molecular Tools Core Facility (RRID:SCR_026201) for our study and injected to label presynaptic inputs to SNr neurons.
pAAVDJ-Esyn-FlpX-TVA950-EYFP-WPRE
By onThis plasmid can be used to label presynaptic inputs to SNr and SNr-IC neurons.
