pGAE-SFFV-BsdR-1x miR2_MmATP13A4_WPRE
By ontransfer plasmid for lentiviral vector production with miR for Mm ATP13A4
pGAE-SFFV-BsdR-1x miR3_MmATP13A4_WPRE
By ontransfer plasmid for lentiviral vector production with miR for Mm ATP13A4
pCHMWS-hATP13A4_WT-IRES-Puro
By ontransfer plasmid for lentiviral vector production expressing Hs ATP13A4 WT
pCHMWS-hATP13A4_WT-Twinstrep-Flag-IRES-Puro
By ontransfer plasmid for lentiviral vector production expressing Hs ATP13A4 WT with Twinstrep-Flag tag
pCHMWS-hATP13A4_E646D-IRES-Puro
By ontransfer plasmid for lentiviral vector production expressing Hs ATP13A4 E646D mutant
pCHMWS-hATP13A4_E646D-Twinstrep-Flag-IRES-Puro
By ontransfer plasmid for lentiviral vector production expressing Hs ATP13A4 E646D mutant with Twinstrep-Flag tag
pCHMWS-hATP13A4_D486N-Twinstrep-Flag-IRES-Puro
By ontransfer plasmid for lentiviral vector production expressing Hs ATP13A4 D486N mutant with Twinstrep-Flag tag
pCHMWS-hATP13A4_E276K-Twinstrep-Flag-IRES-Puro
By ontransfer plasmid for lentiviral vector production expressing Hs ATP13A4 E276K mutant with Twinstrep-Flag tag
Para-subthalamic nucleus adjoins subthalamic nucleus and medial forebrain bundle, major DBS-targets in Parkinsons disease, OCD, and depression
By onThe para-STN is a poorly-defined region near critical DBS targets for PD. Here, we construct anatomical maps of para-STN and STN in multiple species using novel molecular markers in conjunction with FISH and light-sheet microscopy.
Scientists to Study Link Between Pesticides and Parkinson’s
Parkinson’s News Today reports that the ASAP has awarded a $9 million grant to scientists from Cedars-Sinai, to investigate how exposure to specific pesticides and air pollutants interacts with genetic vulnerabilities to trigger the development of the disease.
Structural remodeling of the mitochondrial protein biogenesis machinery under proteostatic stress
By onCryo-ET showed protein aggregates, altered cristae, and reduced ribosome complexes in stressed mitochondria. Mitochondrial Hsp60 undergoes conformational changes to aid in protein folding, shedding light on mitochondrial proteostasis mechanisms.
Excitatory synaptic structural abnormalities produced by templated aggregation of α-syn in the basolateral amygdala
By onPD and DLB involve α-syn inclusions in the amygdala affecting cognition and emotions. Cortico-amygdala synapses with α-syn aggregates show increased volume of synapses, potentially contributing to behavioral impairments.
Philanthropy Funnels $261 Million into Parkinson’s Research
Alzforum dives into the global scale of a $261 million investment by ASAP in partnership with The Michael J. Fox Foundation, which expands the Collaborative Research Network (CRN), to transform Parkinson's research by generating standardized tools and investigating the root causes of the disease.
Single cell eQTL mapping reveals convergent glial–neuronal risk architecture in Parkinson’s disease
By onPopulation-scale, disease-context aware meta single-nucleus eQTLs mapping (N 1,197) in nine cell types from cortex and substantia nigra identifies 125 risk genes and cell types for PD GWAS signals.
Protocol to study synapse density or volume— SynDOVE—in brain using confocal microscopy and Imaris three-dimensional surface rendering software
By onGuide for analyzing for analysis of synaptic loci density and pre- and postsynaptic volumes (SynDOVE). from confocal images of pre- and postsynaptic loci in fixed brain sections with Imaris software.
MJFF and ASAP Invest $261M in Global Network for Parkinson’s Research
Parkinson’s News Today reports that ASAP and The Michael J. Fox Foundation are investing $261 million to expand the Collaborative Research Network (CRN) to better understand what drives Parkinson’s disease and to accelerate the development of more personalized therapies.
Copica, an open-source easy-to-use protein copy number mass spectrometry database
By onAdvances in mass spectrometry allow profiling proteome with 10 ng material. Copica database aids in analyzing and comparing protein abundance in cells and tissues, highlighting specific proteins and enabling easy comparison of datasets.
CURTAIN, A WEB-BASED TOOL FOR DATA VISUALIZATION AND EXPLORATION OF MASS SPECTROMETRY-BASED PROTEOMICS
By onCurtain is a tool for sharing, visualizing, and analyzing mass spectrometry data, designed for non-experts. It allows easy data sharing via web links and displays differential analysis results in interactive plots.
CURTAIN-PTM, A WEB-BASED TOOL FOR DATA VISUALIZATION AND EXPLORATION OF MASS SPECTROMETRY-BASED PROTEOMICS (POST TRANSLATIONAL MODIFICATIONS)
By onCurtain is a tool for sharing, visualizing, and analyzing proteomic and PTM MS data. It allows easy sharing of data via web link, displays results in interactive plots, and enables analysis of protein groups and structure. Free and open-source.
Cactus
By onCactus (10.5281/zenodo.7351087) manages session data for curtain and curtainptm backends, handling saving and loading operations efficiently.
