Single nuclei RNA sequencing (ParseBio) of postmortem cingulate cortex,midbrain and motor cortex of healthy donors and Parkinson’s disease patients
By onThe dataset includes snRNA-seq data from postmortem brain samples of healthy donors, Parkinson's disease patients, and other neurological disorder patients.
Single nuclei RNA sequencing (10x) of postmortem cingulate cortex,midbrain and motor cortex of healthy donors and Parkinson’s disease patients – 10x snRNA-seq
By onDataset contains snRNA-seq data from postmortem brain samples of healthy donors, Parkinson's patients, and other neurological disorder patients.
Single nuclei RNA sequencing of postmortem cingulate cortex,midbrain and motor cortex of healthy donors and Parkinson’s disease patients – 10x multiome (snRNA-seq and snATAC-seq)
By onDataset includes snRNA-seq & snATAC-seq data from postmortem brain samples of healthy donors, Parkinson's patients, and other neurological disorders.
Single nuclei ATAC sequencing of postmortem cingulate cortex,midbrain and motor cortex of healthy donors and Parkinson’s disease patients – 10x snATAC-seq
By onThe dataset includes snATAC-seq data from postmortem brain samples of healthy donors, Parkinson's disease patients, and other neurological disorder patients.
Single nuclei ATAC sequencing of postmortem cingulate cortex,midbrain and motor cortex of healthy donors and Parkinson’s disease patients – Scale-ATAC + 10x Genomics
By onDataset contains ATAC-seq data from midbrain, cingulate cortex, and motor cortex of healthy donors, Parkinson's patients, and other neurological disorder patients.
Single nuclei ATAC sequencing of postmortem cingulate cortex,midbrain and motor cortex of healthy donors and Parkinson’s disease patients – HyDrop-ATAC v2
By onThe dataset contains snATAC-seq data from postmortem brain samples of healthy donors, Parkinson's disease patients, and other neurological disorder patients.
Single nuclei ATAC sequencing of postmortem cingulate cortex,midbrain and motor cortex of healthy donors and Parkinson’s disease patients – Scale-ATAC + HyDrop v2
By onThe dataset contains ATAC-seq data from midbrain, cingulate cortex, and motor cortex of healthy donors, Parkinson's patients, and others.
Nuclei isolation from brain tissue for single-cell ATAC
By onProtocol for isolating nuclei from brain tissue for single-cell ATAC assays like 10X Genomics Chromium Next GEM Single Cell ATAC Kit, HyDrop-ATAC, etc.
Nuclei isolation of fresh frozen human brain samples for for scRNA-seq
By onProtocol for isolating nuclei for single-cell RNA sequencing is detailed.
Long read whole genome sequencing data from brain postmortem tissue
By onDataset includes 172 whole genome sequencing runs from healthy controls and Parkinson's disease patients, sequenced on Oxford Nanopore platform. Data mapped to T2T-CHM13v2.0 reference genome, available in CRAM format.
HyDrop-v2-ATAC
By onProtocol covers nuclei preparation, ATAC tagmentation, microfluidics setup, HyDrop run, PCR1 cleanup, library purification, and quality control for efficient processing.
ATP13A2 Loss of Function-Driven Polyamine Dysregulation Induces SAM Depletion and Epigenetic Astrocyte Toxicity
By onLoss of ATP13A2 function leads to lysosomal polyamine sequestration, depleting cytosolic polyamines in astrocytes. This triggers compensatory polyamine biosynthesis, diverting SAM from DNA methylation and promoting neuroinflammation.
Dopamine release from Parkinson’s patient-derived neurons is disrupted due to impaired synaptic vesicle loading
By onHuman Parkinson's patient neurons with SNCA-triplication mutation exhibit reduced dopamine release due deficits in dopamine loading and handling.
TEsingle enables locus-specific transposable element expression analysis at single-cell resolution
By onTEsingle is a tool for analyzing transposable elements (TE) and gene expression in single-cell data. The tool reveals cell-type specific TE expression in Parkinson's Disease patients' brain tissues.
HeLa PINK1-GFP knock-in cell line
By onA HeLa cell line expressing PINK1 fused to GFP from the endogenous locus was generated using CRISPR–Cas9 nickase–mediated genome editing with homology-directed repair. GFP-positive clones were isolated by fluorescence-activated cell sorting.
Biochemical analysis of PINK1 activation and ubiquitination signaling upon GTPP treatment
By onUbiquitinated proteins were enriched using Halo-m-DSK ubiquitin capture, and GFP-PINK1 complexes were isolated by IP, followed by SDS–PAGE and immunoblotting to assess PINK1 activation and downstream ubiquitination signaling upon GTPP treatment
Tabular data from Mitochondrial Proteostasis Cryo-ET Analysis
By onTabular output data from the Mitochondrial Proteostasis Cryo-ET Analysis as demonstrated in Ehses et al., 2026.
Molecular dynamics flexible fitting output of mHsp60 models into in situ density maps
By onMDFF simulations were performed to evaluate how well atomic models of mHsp60 single rings in different nucleotide states fit the in situ subtomogram averaging density maps by RMSD-based assessment of model–map agreement.
Fluorescence microscopy analysis of PINK1 localization upon GTPP treatment
By onPINK1-GFP Knock-in cells were stained with the mitochondrial membrane potential–dependent dye MitoSpy Red CMXRos and nuclear DNA dye Hoechst 33342 following treatment with 10µM G-TPP over multiple time points.
