TheDongLab/AI2AMP-PD: AI2AMP-PD v1.0
By onAnalysis code to built a novel multi-omics machine learning model to predict PD diagnosis.
A TIRF microscopy-based assay to monitor LRRK2-dependent endo-lysosome exocytosis
By onHere we describe a method for monitoring CD63+ endo-lysosome exocytosis in hTERT-RPE cells stably expressing CD63-pHluorin.
Key Resource table related to publication: Health phenome of Parkinson’s patients reveals prominent mood-sleep cluster
By onThe Key resource table contains all software, code and datasets used in the publication.
G code: 3D bioprinting of human neural tissues with functional connectivity
By onThis is he G code related to the publication Yan et al. 2024 3D bioprinting of human neural tissues with functional connectivity
Raw data of Fig1-7 part of: 3D bioprinting of human neural tissues with functional connectivity
By onThis are the tabular raw data related to the paper "3D bioprinting of human neural tissues with functional connectivity". DOI: 10.1016/j.stem.2023.12.009
Lentivirus preparation using Lenti-X Concentrator
By onThis protocol describes the preparation of Lenti-GCaMP6 viral particles using a 2nd generation lentiviral system.
Lenti-jRGECO1b and lenti-iGluSnFR virus preparation
By onThis protocol describes the preparation of EF1-jRGECO1b and EF1-iGluSnFR lentiviral particles using HEK293T cells.
Immunofluorescence and quantification
By onThis protocols describes the immunofluorescence staining and image quantification published in: 3D bioprinting of human neural tissues with functional connectivity DOI: 10.1016/j.stem.2023.12.009
Whole-cell patch-clamp of PSC-derived cortical glutamatergic and GABAergic neurons
By onThis protocol describes whole-cell-patch-clamp of PSC-derived cortical glutamatergic and GABAergic neurons.
Key Resource Table (KRT) related to publication: Bukhari et al., 2024 Transcriptional programs mediating neuronal toxicity and altered glial-neuronal signaling in a Drosophila knock-in tauopathy model
By onHere you can find the Key resource table realted to the publication: Bukhari et al., 2024 Transcriptional programs mediating neuronal toxicity and altered glial-neuronal signaling in a Drosophila knock-in tauopathy model.
Data related to publication: Transcriptional programs mediating neuronal toxicity and altered glial-neuronal signaling in a Drosophila knock-in tauopathy model
By onAll tabular data related to the publication Bukhari et al., 2024, Transcriptional programs mediating neuronal toxicity and altered glial-neuronal signaling in a Drosophila knock-in tauopathy model are deposited here.
Key Resource Table (KRT) related to publication: Nithianandam et al., 2024 Pathways controlling neurotoxicity and proteostasis in mitochondrial complex I deficiency
By onThe key resource table includes persistent identifiers for all the data, code, software, protocols and key materials that were used for this manuscript.
Data related to publication: Pathways controlling neurotoxicity and proteostasis in mitochondrial complex I deficiency
By onTabular data of the publication: Nithianandam et al., 2024, Pathways controlling neurotoxicity and proteostasis in mitochondrial complex I deficiency
PD5D single-nucleus MTG RNA-seq hybrid selection
By onThis dataset contains the raw data in FASTQ format for single-nucleus RNA sequencing (snRNAseq) enriched with Agilent SureSelect for reads from a list of targeted transcripts for human middle temporal gyrus (MTG).
PD5D_MTG_snRNAseq
By onThis dataset contains single-nucleus RNA sequencing (snRNAseq) raw data in FASTQ format for 94 human middle temporal gyrus (MTG) samples from Parkinson's patients and healthy controls.
ASE_Plots
By onA repo with many of the scripts used for downstream analysis in our paper and for making figures.
Key Resource Table for the paper “Experimental and computational methods for allelic imbalance analysis from single-nucleus RNA-seq data”
By onThe key resource table to go with the publication "Experimental and computational methods for allelic imbalance analysis from single-nucleus RNA-seq data" by Simmons et al.
Hybrid selection protocol using 10x Single-Cell RNA-Seq assay library
By onThis protocol is for target enrichment of cDNA libraries generated with 10x Genomics single-cell RNA-seq assays.
Rise-and-fall dynamics reveal a molecular and cellular vulnerability axis in prion-like α-synuclein propagation
By onThis study uses a mathematical model to analyze α-synuclein pathology in a Parkinson’s mouse model. It identifies a low-dimensional vulnerability axis linking regional dynamics to neuronal composition and gene expression.
