Single cell eQTL mapping reveals convergent glial–neuronal risk architecture in Parkinson’s disease
By onPopulation-scale, disease-context aware meta single-nucleus eQTLs mapping (N 1,197) in nine cell types from cortex and substantia nigra identifies 125 risk genes and cell types for PD GWAS signals.
CREsted: modeling genomic and synthetic cell-type-specific enhancers across tissues and species
By onCREsted, a sequence-based deep learning model, analyzes genomic regulatory code, decodes enhancer grammar, and designs synthetic enhancers. It preprocesses single-cell data, models chromatin accessibility, and compares cell states across tissues.
EnvA-N2c-deltaG-H2B-HA-FlpO
By onGenerated for anatomical anterograde tracing experiments by Columbia University Zuckerman Institute Molecular Tools Core Facility (RRID:SCR_026201).
FushikiA_etal_2024: PD Model Mice Study – v1.0 Code
By onRepository offers tools for processing, analyzing, and visualizing data related to PD and dopaminergic neurons.
pAAVDJ-Ef1a-FDOI-mScarlet
By onGenerated for anatomical tracing experiments by Columbia University Zuckerman Institute Molecular Tools Core Facility (RRID:SCR_026201).
A druggable ATP13A3–antizyme switch controls adaptive polyamine uptake in cancer
By onCellular polyamine depletion for cancer treatment is hindered by compensatory uptake. ATP13A3, not ATP13A2, is the key polyamine importer affected by DFMO. Antizyme inhibits uptake by ATP13A3, suggesting a targetable strategy for cancer therapy.
A single Citrobacter rodentium infection in Pink1 knockout and wild type mice leads to regional blood-brain-barrier perturbation and limited microglial activation without dopamine neuron axon terminal loss
By onResearch suggests immune system activation may contribute to Parkinson’s disease development. Mild infections can increase BBB permeability, triggering brain inflammation in genetically susceptible individuals, potentially leading to PD pathology.
Dataset for “A single Citrobacter rodentium infection in Pink1 knockout and wild-type mice leads to regional blood-brain-barrier perturbation and limited microglial activation without dopamine neuron axon terminal loss”
By onImmune system activation may contribute to PD development. Infection increases BBB permeability in mice, leading to brain inflammation. This suggests infections could trigger PD in genetically susceptible individuals.
Generation of DATcrePink1 Knockout Mice Expressing tdTomato in Dopaminergic Neurons
By onProtocol details generation of DATcrePink1 mice expressing tdTomato in dopaminergic neurons. Covers Pink1 KO, HET, WT variants, animal housing, breeding, and genotyping procedures.
Semi-automated quantification of microglial CD68 and Iba1 immunohistochemistry signal in mouse brain slices
By onA standardized method for semi-automated detection and quantification of CD68 and Iba1 in brain sections using image acquisition, AI segmentation, and data analysis.
Automated Quantification of Dopaminergic Neurons in Floating Sections V.1
By onAutomated method for detecting and measuring dopaminergic neurons in brain sections using image capture, AI segmentation, and data analysis in SNc and VTA regions.
STING dampens the unfolded protein response to enable the presentation of self antigens on MHC-I during inflammation
By onSTING pathway regulates antigen presentation through the UPR, impacting immune response in PD and autoimmune diseases. Targeting STING and UPR could be therapeutic.
Dataset for “STING dampens the unfolded protein response to enable the presentation of self-antigens on MHC-I during inflammation”
By onSTING pathway activation impacts antigen presentation through the UPR and may be a target for therapeutic intervention in PD and autoimmune diseases.
Protocols for “LRRK2 mutations block NCOA4 trafficking upon iron overload leading to ferroptotic death”
By onLRRK2-G2019S affects iron homeostasis in macrophages by dysregulating iron-related proteins. This leads to impaired ferritinophagy, increased oxidative stress, and cell death, highlighting LRRK2's role in iron regulation in Parkinson's Disease.
An LRRK2 variant blocks NCOA4 trafficking upon iron overload, leading to ferroptotic death
By onWe examined the impact of mutant LRRK2-G2019S on iron homeostasis within a model macrophage cell line. Results revealed a dysregulation of iron-related proteins in steady state and a complete block in the degradation of the ferritinophagy NCOA4.
Protocols for “STING dampens the unfolded protein response to enable the presentation of self-antigens on MHC-I during inflammation”
By onSTING pathway regulates MitAP through the UPR, establishing it as a key immune regulator in autoimmunity and PD.
Dataset for “An LRRK2 variant blocks NCOA4 trafficking upon iron overload, leading to ferroptotic death”
By onLRRK2 as a key regulator of iron homeostasis and point to the need for an increased focus on the mechanisms of iron dysregulation in PD
