Datasets for Murray et al. 2026 (Prolonged Timescales) Manuscript
By onTrial information, dopamine data, and autonomic/behavioral data used for the prolonged timescales Murray et al. 2026 manuscript
CRN Cloud Training Videos
By onThese training videos are intended to provide an introduction to CRN Cloud and the getting started resources available.
Neural Control of Autonomic Arousal During Threat Anticipation Revealed by High-Resolution Cardiac Contractility
By onThese findings highlight neural correlates of adaptive behavioral mobilization during emotion-guided action, shedding light on motor circuitry that may be engaged during paradoxical kinesia, a phenomenon of emotion-relevant motor facilitation in PD.
Code for Murray et al. 2026 (Prolonged Timescales) Manuscript
By onSource code to replicate core analyses used throughout the Murray et al. 2026 (Prolonged Timescales) manuscript.
Data and code for Stasiak et al. 2026 (TREV-Emotion) Manuscript
By onOnline repository for the data and scripts used in the Stasiak et al., 2026 preprint on TREV-derived cardiac contractility in threat anticipation contexts.
Protocol for Stasiak et al. 2026 (TREV-Emotion) Manuscript
By onProtocol for Stasiak et al. 2026 (TREV-Emotion) Manuscript. Describes participant preparation, shock calibration, scan sequence, active escape task, and participant debriefing.
Distinct amygdalar pathways to frontopolar cortex and medial temporal lobe support temporal memory for emotional events
By onAmygdala pathways shaped temporal memory for emotional images, some sharpening it, others blurring it. Since related circuits drive paradoxical kinesia in PD, our findings may explain memory and cognitive decline in PD dementia.
Opto-Open Field Test
By onProtocol for optogenetic open field test, which records mouse behavior in an open field arena in response to alternating 5-minute periods of optogenetic stimulation.
Stereotaxic virus injection and fiber optic probe implantation
By onThis protocol serves to prepare mice for in vivo optogenetic stimulation.
Opto-Avoidance-EPM Test
By onThe Opto-Avoidance-Elevated Plus Maze test assesses the effect induced by photostimulation compared to a mouse's natural aversion to open areas.
Opto-RT-CPP Test
By onProtocol for Opto-RT-CPP (Optogenetic Real-Time Conditioned Place Preference) test. This test measures location preference or avoidance in response to optogenetic stimulation.
Opto-Negative Reinforcement Paradigm (Opto-NR)
By onProtocol for Opto-Negative Reinforcement paradigm (Opto-NR). This test uses an operant conditioning box with two nose-poke devices to test aversive learning in mice.
Sugar Positive Reinforcement Paradigm (Sugar-PR)
By onProtocol for Sugar Positive Reinforcement Paradigm (Sugar-PR) with optogenetic stimulation.
Post-injection Histological Analysis
By onProtocol for post-injection histological analysis following optogenetic behavioral assays.
Sparking Discoveries for Parkinson’s Research: CRN Impact Report 2025-2026
In this blog, ASAP shares an overview of the Collaborative Research Network (CRN) 2025–2026 Impact Report, highlighting key discoveries, cross-cutting scientific themes, field-enabling resources, and infrastructure efforts accelerating breakthroughs in Parkinson's disease research.
Excitatory synaptic structural abnormalities produced by templated aggregation of α-syn in the basolateral amygdala
By onPD and DLB involve α-syn inclusions in the amygdala affecting cognition and emotions. Cortico-amygdala synapses with α-syn aggregates show increased volume of synapses, potentially contributing to behavioral impairments.
EnvA-N2c-deltaG-H2B-HA-FlpO
By onGenerated for anatomical anterograde tracing experiments by Columbia University Zuckerman Institute Molecular Tools Core Facility (RRID:SCR_026201).
FushikiA_etal_2024: PD Model Mice Study – v1.0 Code
By onRepository offers tools for processing, analyzing, and visualizing data related to PD and dopaminergic neurons.
pAAVDJ-Ef1a-FDOI-mScarlet
By onGenerated for anatomical tracing experiments by Columbia University Zuckerman Institute Molecular Tools Core Facility (RRID:SCR_026201).
A druggable ATP13A3–antizyme switch controls adaptive polyamine uptake in cancer
By onCellular polyamine depletion for cancer treatment is hindered by compensatory uptake. ATP13A3, not ATP13A2, is the key polyamine importer affected by DFMO. Antizyme inhibits uptake by ATP13A3, suggesting a targetable strategy for cancer therapy.
