From structure to ætiology: a new window on the biology of leucine-rich repeat kinase 2 and Parkinson’s disease
By Michelle onReview: This review summarizes LRRK2 structure both in a historical and current context, highlighting new insights into the structure of LRRK2 and complexes it forms.
Integrating protein networks and machine learning for disease stratification in the Hereditary Spastic Paraplegias
By Michelle onPublished: Hereditary Spastic Paraplegias are a group of neurodegenerative disorders with diverse clinical presentation and genetic variability. The authors used validated human data to create a protein-protein interaction map using causative genes to identify core proteins and processes. View original preprint.
Insights into VPS13 properties and function reveal a new mechanism of eukaryotic lipid transport
By Blythe Lloyd onReview: This review focuses on the disssecting the VPS13 family of proteins and their novel role in mediating lipid transfer between organelles.
Presynaptic autophagy is coupled to the synaptic vesicle cycle via ATG-9
By Blythe Lloyd onPublished: ATG9 is a core autophagy transmembrane protein present at nerve terminals. The authors found that ATG9 is a component of vesicles that undergo exo-endocytosis at synapses and that synaptojanin 1 mutations disrupt ATG9 activity at synapses. View original preprint.
VPS13D bridges the ER to mitochondria and peroxisomes via Miro
By Blythe Lloyd onPublished: VPS13C mutations are implicated in PD. The authors found that VPS13D, a closely related protein, can mediate a bridge between the peroxisome and different organelles (ER or mitochondria). Authors identified the specific ER and mitochondrial proteins facilitating this interaction resulting in dysregulation of lipid flux between them. View original preprint.
Reconstitution of cargo-induced LC3 lipidation in mammalian selective autophagy
By taliag onGUV quantification
ALS and FTD-associated missense mutations in TBK1 differentially disrupt mitophagy
By taliag onRaw data associated with DOI: 10.1073/pnas.2025053118
Parkinson’s disease and cancer: a systematic re and meta-analysis of over 17 million participants
By Blythe Lloyd onPublished: The authors examined risk association between Parkinson’s disease and cancer using data from 63 publications, totaling in 17 million individuals. With the exception of melanoma, the authors found that the risk association of Parkinson’s disease and cancer was inversely related.