3D-correlative FIB-milling and Cryo-ET of Autophagic structures in Yeast Cells

Output Details

This protocol describes how to plunge-freeze yeast on EM grids and how to target autophagic structures by combining cryo confocal fluorescence data to FIB-milling and tomogram acquisition.

Tags
  • Autophagy
  • Cryo-ET

Meet the Authors

  • Cristina Capitanio, MSc

    Key Personnel: Team Harper

    Max Planck Institute of Biochemistry

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    Anna Bieber, MSc

    Key Personnel: Team Harper

    Max Planck Institute of Biochemistry

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    Philipp S. Erdmann

  • Brenda Schulman, PhD

    Co-PI (Core Leadership): Team Harper

    Max Planck Institute of Biochemistry

  • Florian Wilfling, PhD

    Collaborating PI: Team Harper Team Hurley

    Max Planck Institute of Biophysics

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    Wolfgang Baumeister