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Bolen CosMx human Colon RNA and Protein code
onRepository for the paper "Spatial single-cell multiomics..." includes CosMx assays, README files with scripts/data for analysis, and computational environment requirements. It also features a tissue microarray image showing morphology markers.
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Multi-omics reveal critical differentiation target for Parkinson’s Disease-vulnerable midbrain dopaminergic neurons
onWe describe a multiomic-guided strategy that enriches SOX6+ mDA neurons by combining enhancing Sonic Hedgehog agonism with prolonged Wnt activation. This work is a reproducible differentiation platform for generating the PD-susceptible mDA subtype
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Tansey Stool Meso Scale Discovery
onStool samples of healthy controls and individuals with either PD or IBD analyzed for chemokines, cytokines, and ferritin levels using U-PLEX and R-PLEX assays on Quickplex MSD instrument.
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Bolen Human Sigmoid Colon Protein CosMx Datasets
onProtein dataset from NanoString CosMx includes sigmoid colon samples from healthy controls, Parkinson's disease, and inflammatory bowel disease patients for analysis.
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Tansey Plasma Meso Scale Discovery
onPlasma samples from individuals with Parkinson's disease, inflammatory bowel disease, or healthy controls were analyzed to measure chemokines and cytokines. The study used Quickplex MSD instrument following manufacturer's protocol.
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Bolen Human Sigmoid Colon RNA CosMx Dataset
onNanoString CosMx RNA dataset from human sigmoid colon of healthy controls, Parkinson's Disease, or inflammatory bowel disease exported for analysis.
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Striatal ensembles specify and control granular forelimb actions
onThe striatum plays a crucial role in controlling movements and learning. These results reveal specific ensembles of both D1- and D2-MSNs causally control specific ongoing actions, as granular as different muscle co-contractions of the same forelimb.
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GRIN lens implant (1 mm) Protocol
onThis is the standard 1 mm GRIN lens implant protocol for Rodrigues-Vaz and Athalye et al, 2025.
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EMG recordings-Rodrigues-Vaz and Athalye et al, 2025
onThis is the standard protocol for recordings of bulk EMG used for Rodrigues-Vaz and Athalye et al, 2025.
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Perfusion and Histology Rodrigues-Vaz and Athalye et al, 2025
onThis is the standard protocol for perfusion and histology of brain slices for Rodrigues-Vaz and Athalye et al, 2025.
