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Dynamic basal ganglia output signals license and suppress forelimb movements
onBasal ganglia is fundamental to motor control and dysfunction is linked to motor deficits. Our results demonstrate the existence and function of highly specific and temporally precise movement representations in basal ganglia output circuitry.
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Mouse Stereotaxic Surgery-Arber Lab
onThis protocol describes the steps for performing stereotaxic surgery in mice. It is applicable to intracranial injections (e.g. virus, drug) and placement of implants (e.g. optical fibers, electrode arrays) into targeted regions of mouse brains.
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AAV Production Protocol-Arber Lab
onAAV Production methods used in Falasconi & Kanodia et al 2025 and is the general protocol for Arber Lab.
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Immunohistochemistry & Microscopy-Falasconi & Kanodia et al 2025
onImmunohistochemistry and microscopy methods used in Falasconi & Kanodia et al 2025.
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Immunostaining and Western blot images
onRaw immunostaining and western blot images included in Adami et al, 2025.
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The bridge-like lipid transport protein VPS13C/PARK23 mediates ER-lysosome contacts upon lysosome damage
onGenetic studies link lysosome dysfunction to Parkinson's disease. VPS13C, a PD gene, relocates to damaged lysosomes, aiding in membrane repair. This process involves Rab7 and suggests early lipid transport as a protective response.
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CREsted: modeling genomic and synthetic cell type-specific enhancers across tissues and species
onDeep learning models decode genomic regulatory codes well, especially enhancers. CREsted enables end-to-end enhancer modeling, design, and analysis, proving effective across datasets and species through comprehensive training and evaluation.
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HyDrop v2: Scalable atlas construction for training sequence-to-function models
onSingle-cell chromatin accessibility data helps train deep learning models to decode enhancer logic. HyDrop v2 improves data generation across species, organs, and diseases, delivering results comparable to commercial platforms like 10x Genomics.
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Tissue Isolation of the Region Around Locus Coeruleus for Single Nucleus RNA Profiling
onIsolating tissue from the peri-locus coeruleus region in mice for single nucleus RNA
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Stereotaxic virus injection in the SNpc of rats
onProtocol for stereotaxic virus injection in the substantia nigra pars compacta of rats
