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An ImageJ/FIJI Preprocessing Workflow for Multi-Series Confocal Microscopy Datasets Prior To CellProfiler Analysis
onA workflow using ImageJ/FIJI aims to create three-slice MIPs from multi-series .czi files to capture weak signals. It involves extracting datasets, creating projections, and saving images for efficient analysis in CellProfiler.
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State-dependent modulation of spiny projection neurons controls levodopa-induced dyskinesia in a mouse model of Parkinson’s disease
onLID is poorly understood, our research on dyskinetic mice show SPNs' properties oscillate during LID and are influenced by dopamine and acetylcholine signaling. Targeting M1 receptors in iSPNs reduced LID severity and improved levodopa effects.
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Excitatory synaptic structural abnormalities produced by templated aggregation of α-syn in the basolateral amygdala
onPD and DLB involve α-syn inclusions in the amygdala affecting cognition and emotions. Cortico-amygdala synapses with α-syn aggregates show increased volume of synapses, potentially contributing to behavioral impairments.
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Striatal dopamine signals internal states related to behavioral performance over prolonged timescales in monkeys
onDopamine plays dual roles in behavior: fast reward prediction errors and slow motivational states. Dopamine release in monkeys' brain regions tracks performance changes, suggesting a single signal for both functions.
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Single cell eQTL mapping reveals convergent glial–neuronal risk architecture in Parkinson’s disease
onPopulation-scale, disease-context aware meta single-nucleus eQTLs mapping (N 1,197) in nine cell types from cortex and substantia nigra identifies 125 risk genes and cell types for PD GWAS signals.
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CREsted: modeling genomic and synthetic cell-type-specific enhancers across tissues and species
onCREsted, a sequence-based deep learning model, analyzes genomic regulatory code, decodes enhancer grammar, and designs synthetic enhancers. It preprocesses single-cell data, models chromatin accessibility, and compares cell states across tissues.
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EnvA-N2c-deltaG-H2B-HA-FlpO
onGenerated for anatomical anterograde tracing experiments by Columbia University Zuckerman Institute Molecular Tools Core Facility (RRID:SCR_026201).
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FushikiA_etal_2024: PD Model Mice Study – v1.0 Code
onRepository offers tools for processing, analyzing, and visualizing data related to PD and dopaminergic neurons.
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pAAVDJ-Ef1a-FDOI-mScarlet
onGenerated for anatomical tracing experiments by Columbia University Zuckerman Institute Molecular Tools Core Facility (RRID:SCR_026201).
