The authors assess the activity and structural plasticity of corticostriatal axons during learning in the adult mouse brain. The structural and functional imaging show bouton reorganization to support motor skill acquisition.
Cholinergic neurons (CNs) in the pedunculopontine nucleus (PPN) are lost in the course of Parkinson’s disease. PPN CNs have a distinctive physiological phenotype that shares only some of the features of other selectively vulnerable neurons in PD.
