The authors assess the activity and structural plasticity of corticostriatal axons during learning in the adult mouse brain. The structural and functional imaging show bouton reorganization to support motor skill acquisition.
LID is poorly understood, our research on dyskinetic mice show SPNs' properties oscillate during LID and are influenced by dopamine and acetylcholine signaling. Targeting M1 receptors in iSPNs reduced LID severity and improved levodopa effects.
