Combining biomarkers for prognostic modelling of Parkinson’s disease

By Raquel Real, PhD, Ed Jabbari, Roger Barker, PhD, Nicholas Wood, PhD, John Hardy, PhD, Huw Morris, Christine Girges, Viorica Chelban, Katherine A Grosset, John Woodside, Manuela Tan, Tong Guo, Michael Lawton, Amanda Heslegrave, Nirosen Vijiaratnam, Ben-Shlomo Yoav, Thomas Foltynie, Henry Houlden, Henrik Zetterberg, Dilan Athauda, Nigel Williams and Donald Grosset

Published July 12, 2022

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Description

Patients with Parkinson’s disease (PD) have variable rates of progression. More accurate prediction of progression could improve selection for clinical trials. Although some variance in clinical progression can be predicted by age at onset and phenotype, we hypothesise that this can be further improved by blood biomarkers. We evaluated the relationship between serum NfL and baseline and longitudinal clinical measures as well as patients’ genetic (GBA and APOE) status.

Identifier (DOI)

10.1136/jnnp-2021-328365

Tags

APOE (Apolipoprotein E)
Biomarkers
Blood
DNA
GBA (Glucocerebrosidase)
Genotyping
Motor symptoms
NfL (Neurofilament light)
Original Research
Prognostic modeling
SNPs (Single Nucleotide Polymorphisms)

Team

Team Hardy

Program

Collaborative Research Network

Theme

PD Functional Genomics

Meet the Authors

Raquel Real, PhD

Key Personnel: Team Hardy,

University College London
Ed Jabbari

Key Personnel: Team Hardy,

University College London
Roger Barker, PhD

Co-PI (Core Leadership): Team Jakobsson,

University of Cambridge
Nicholas Wood, PhD

Lead PI (Core Leadership): Team Wood,

University College London
John Hardy, PhD

Lead PI (Core Leadership): Team Hardy,

University College London
Huw Morris

Collaborating PI: Team Hardy,

University College London
Christine Girges

External Collaborator
Viorica Chelban

External Collaborator
Katherine A Grosset

External Collaborator
John Woodside

External Collaborator
Manuela Tan

External Collaborator
Tong Guo

External Collaborator
Michael Lawton

External Collaborator
Amanda Heslegrave

External Collaborator
Nirosen Vijiaratnam

External Collaborator
Ben-Shlomo Yoav

External Collaborator
Thomas Foltynie

External Collaborator
Henry Houlden

External Collaborator
Henrik Zetterberg

External Collaborator
Dilan Athauda

External Collaborator
Nigel Williams

External Collaborator
Donald Grosset

External Collaborator