Development and characterization of a non-human primate model of diseeminated synucleinopathy
Output Details
Description
Here we took advantage of a retrogradely-spreading adeno-associated viral vector serotype 9 coding for the alpha-synuclein A53T mutated gene to induce a
widespread synucleinopathy of cortical and subcortical territories innervating the putamen. Four weeks post-AAV deliveries animals were sacrificed and a comprehensive biodistribution study was conducted, comprising the
quantification of neurons expressing alpha-synuclein, rostrocaudal distribution and their specific location.
Identifier (DOI)
10.17504/protocols.io.81wgbxwnylpk/v1
