Development and characterization of a non-human primate model of disseminated synucleinopathy

By Alberto J Rico, PhD, Almudena Corcho, Julia Chocarro Garcia, MSc, Goiaz Ariznabarreta, Elvira Roda, Adriana Honrubia, Patricia Arnaiz and José Luis Lanciego, MD, PhD
View Published Dataset

Output Details

Description
In this study, the performance and biodistribution of the retrogradely-spreading AAV9-SynA53T vector was evaluated in the NHP brain. Conducted intraparenchymal deliveries of viral suspensions in the left putamen gave rise to a disseminated synucleinopathy in a circuit-specific basis.
Tags
  • In Vivo
  • Non-human primate
Team
Team Vila
Program
Collaborative Research Network
Theme
Circuitry and Brain-Body Interactions

Meet the Authors

  • User avatar fallback logo

    Alberto J Rico, PhD

    Key Personnel: Team Vila, 

    CIMA Research Foundation

  • User avatar fallback logo

    Almudena Corcho

  • User avatar fallback logo

    Julia Chocarro Garcia, MSc

    Key Personnel: Team Vila, 

    Open University of Catalonia

  • User avatar fallback logo

    Goiaz Ariznabarreta

    Key Personnel: Team Vila, 

    CIMA Research Foundation

  • User avatar fallback logo

    Elvira Roda

    Environmental Development Centre

  • User avatar fallback logo

    Adriana Honrubia

    Key Personnel: Team Vila, 

    Environmental Development Centre

  • User avatar fallback logo

    Patricia Arnaiz

    Key Personnel: Team Vila, 

    CIMA Research Foundation

  • José Luis Lanciego, MD, PhD

    Collaborating PI: Team Vila, 

    Biomedical Research Networking Center on Neurodegenerative Diseases

Related Research

Dan Lab sleep datasets for MCI-Park mice 24-hour recordings

Sleep-wake dataset for MCI-Park mice and wildtype controls from Dan Lab.

View Dataset

Datasets and Key Resources Table used in Bouabid, S. et al. (2025) “Distinct spatially organized striatum-wide acetylcholine dynamics for the learning and extinction of Pavlovian associations””

This repository contains a 1) Key Resources Table with details on key resources and the persistent identifiers for protocols and code used and generated in this study; 2) Source Data Folder, and 3) Supplementary Data Folder.

View Dataset

Fabrication and calibration of multi-fiber arrays to monitor dopamine release in the mouse striatum

A new method allows monitoring dopamine release in mice with high spatial and temporal resolution in multiple locations in the striatum simultaneously using a fluorescent sensor. The protocol involves array fabrication and pre-implant mapping.

View Protocol
View More Outputs
Aligning Science Across Parkinson's
Powered by  GDPR Cookie Compliance
Privacy Overview

This website uses cookies so that we can provide you with the best user experience possible. Cookie information is stored in your browser and performs functions such as recognising you when you return to our website and helping our team to understand which sections of the website you find most interesting and useful.