Expansion Microscopy

By Michela Deleidi, MD, PhD, Maria Jose Perez Jimenez, PhD and Hariam Raji, MSc
View Published Protocol

Output Details

Description
Expansion microscopy is a technique to visualize biological structures with higher spatial resolution than traditional microscopy methods.
Identifier (DOI)
10.17504/protocols.io.j8nlkwp56l5r/v1
Tags
  • Microscopy
Team
Team Schapira
Program
Collaborative Research Network
Theme
Neuro-Immune Interactions

Meet the Authors

Related Research

Glucocerebrosidase is imported into mitochondria and preserves complex I integrity and energy metabolism

Mutations in GBA1, the gene encoding the lysosomal enzyme β-glucocerebrosidase (GCase), which cause Gaucher’s disease, are the most frequent genetic risk factor for Parkinson’s disease (PD). Here, we employ global proteomic and single-cell…

View Article

Immunohistochemistry & Microscopy-Falasconi & Kanodia et al 2025

Immunohistochemistry and microscopy methods used in Falasconi & Kanodia et al 2025.

View Protocol

GPNMB is a biomarker for lysosomal dysfunction and is secreted via LRRK2-modulated lysosomal exocytosis

*GPNMB* is linked to Parkinson's Disease as a risk factor, affecting its transcription and protein levels in CSF. Macrophages secrete GPNMB in response to lysosomal stress through lysosomal exocytosis, with LRRK2 influencing its secretion.

View Article
View More Outputs
Aligning Science Across Parkinson's
Powered by  GDPR Cookie Compliance
Privacy Overview

This website uses cookies so that we can provide you with the best user experience possible. Cookie information is stored in your browser and performs functions such as recognising you when you return to our website and helping our team to understand which sections of the website you find most interesting and useful.