fcs files to “The extracellular chaperone Clusterin enhances Tau aggregate seeding in a cellular model”
Output Details
- Aggregation
- Cell culture
- Chaperones
Meet the Authors
-
Patricia Yuste-Checa
External Collaborator
-
-
Irene Riera-Tur
External Collaborator
-
Rahmi Imamoglu
External Collaborator
-
Theresa F. Schaller
External Collaborator
-
Huping Wang
External Collaborator
-
Irina Dudanova
External Collaborator
-
Mark S. Hipp
External Collaborator
-
Related Research
Spatial transcriptomics reveals molecular dysfunction associated with Lewy pathology
The results identify neurons vulnerable to Lewy pathology in the PD cortex and identify a conserved signature of molecular dysfunction in both mice and humans.
The emerging role of LRRK2 in tauopathies
Parkinson’s disease (PD) is conventionally described as an α-synuclein aggregation disorder, defined by Lewy bodies and neurites, and mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common autosomal dominant cause of PD. However,…
Mitochondrial oxidant stress promotes α-synuclein aggregation and spreading in mice with mutated glucocerebrosidase
In this study, heterozygous expression of a common glucocerebrosidase variant, was found to exacerbate α-synuclein aggregation and spreading in a mouse model of Parkinson-like pathology targeting neurons of the medullary vagal system.